J
John M. Dawes
Researcher at John Radcliffe Hospital
Publications - 26
Citations - 1287
John M. Dawes is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Neuropathic pain & Chronic pain. The author has an hindex of 16, co-authored 25 publications receiving 1041 citations. Previous affiliations of John M. Dawes include King's College London & Wolfson Centre for Age-Related Diseases.
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Journal ArticleDOI
The role of the immune system in the generation of neuropathic pain.
TL;DR: An important challenge for the future is to establish to what extent this immune response initiates or maintains neuropathic pain in patients and thus whether it is amenable to therapy.
Journal ArticleDOI
ReadqPCR and NormqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data
James R. Perkins,John M. Dawes,Steve B. McMahon,David L.H. Bennett,Christine A. Orengo,Matthias Kohl +5 more
TL;DR: These packages increase the repetoire of RT-qPCR analysis tools available to the R user and allow them to (amongst other things) read their data into R, hold it in an ExpressionSet compatible R object, choose appropriate reference genes, normalise the data and look for differential expression between samples.
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Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.
John M. Dawes,Greg A. Weir,Steven J. Middleton,Ryan Patel,Kim I. Chisholm,Philippa Pettingill,Liam J Peck,Joseph Sheridan,Akila Shakir,Leslie Jacobson,Maria Gutierrez-Mecinas,Jorge Galino,Jan Walcher,Johannes Kühnemund,Hannah Kuehn,Maria D. Sanna,Bethan Lang,Alex J. Clark,Andreas C. Themistocleous,Noboru Iwagaki,Steven J. West,Karolina Werynska,Liam S. Carroll,Teodora Trendafilova,David A. Menassa,Maria Pia Giannoccaro,Ester Coutinho,Ilaria Cervellini,Damini Tewari,Camilla Buckley,M. Isabel Leite,Hendrik Wildner,Hanns Ulrich Zeilhofer,Hanns Ulrich Zeilhofer,Elior Peles,Andrew J. Todd,Stephen B. McMahon,Anthony H. Dickenson,Gary R. Lewin,Angela Vincent,David L.H. Bennett +40 more
TL;DR: This is the first example of passive transfer of an autoimmune peripheral neuropathic pain disorder and demonstrates that CASPR2 has a key role in regulating cell-intrinsic dorsal root ganglion (DRG) neuron excitability.
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CXCL5 mediates UVB irradiation-induced pain.
John M. Dawes,Margarita Calvo,James R. Perkins,Kathryn J. Paterson,Hannes Kiesewetter,Carl Hobbs,Timothy K. Y. Kaan,Christine A. Orengo,David L.H. Bennett,David L.H. Bennett,Stephen B. McMahon +10 more
TL;DR: A clear correlation of the UVB response in rat and in human skin was shown, giving the authors confidence that their rat results would apply in humans, as well as proof that a neutralizing antibody to the chemokine protected against the pain and infiltration of immune cells.
Journal ArticleDOI
Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury
Katalin Bartus,Jorge Galino,Nicholas D. James,Luis R. Hernandez-Miranda,John M. Dawes,Florence R. Fricker,Alistair N. Garratt,Alistair N. Garratt,Stephen B. McMahon,Matt S. Ramer,Carmen Birchmeier,David L.H. Bennett,Elizabeth J. Bradbury +12 more
TL;DR: It is shown that neuregulin-1 promotes differentiation of spinal cord-resident precursor cells into PNS-like Schwann cells, which remyelinate central axons and promote functional recovery after spinal cord injury.