Timothy R. Arnett

TL;DR: An increase in the proportion of cells having morphological features characteristic of apoptosis, characteristic apoptotic changes in the nucleus, time-dependent increase inThe percentage of fragmented chromosomal DNA, down-regulation in bcl-2 protein and proteolytic cleavage of PARP, all indicate that bisphosphonates have direct anti-tumour effects on human breast cancer cells.

TL;DR: This is the first direct demonstration that low pH stimulates cell-mediated bone resorption, an observation that may have considerable physiological and pathophysiological significance.

TL;DR: Evidence that Wnts also regulate osteoclast formation and bone resorption is provided, through a mechanism involving transcriptional repression of the gene encoding the osteoclineogenic cytokine receptor activator of NFκB ligand (RANKL or TNFSF11) expressed by osteoblasts.

TL;DR: The inhibitory effects of the peptides used in this study produced effects on dentine resorption which were generally weaker and variable, although osteoclast cell adhesion was consistently inhibited in an Arg-Gly-Asp (RGD)-dependent manner, demonstrating that osteOClast function can be disrupted by low concentrations of the anti-vitronectin receptor antibody, 23C6.

TL;DR: The experiments reveal a previously‐overlooked mechanism of considerable potential importance for the regulation of bone destruction, which may help explain the bone loss associated with a wide range of pathological states involving local or systemic hypoxia, and emphasize the importance of the vasculature in bone.