T
Timothy Rajakumar
Publications - 3
Citations - 47
Timothy Rajakumar is an academic researcher. The author has contributed to research in topics: Biology & Somatic evolution in cancer. The author has an hindex of 1, co-authored 3 publications receiving 47 citations.
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Spatially resolved clonal copy number alterations in benign and malignant tissue
Andrew Erickson,Mengxiao He,Emelie Berglund,Maja Marklund,Reza Mirzazadeh,Niklas Schultz,Linda Kvastad,Alma Andersson,Ludvig Bergenstråhle,Joseph Bergenstråhle,Ludvig Larsson,Leire Alonso Galicia,Alia Shamikh,Elisa Basmaci,Teresita Díaz de Ståhl,Timothy Rajakumar,Dimitrios Doultsinos,Kim Thrane,Andrew L. Ji,Paul A. Khavari,Firaz Tarish,Anna Tanoglidi,Jonas Maaskola,Richard Colling,Tuomas Mirtti,Freddie C. Hamdy,Dan J. Woodcock,Thomas Helleday,Ian G. Mills,Alastair D. Lamb,Joakim Lundeberg +30 more
TL;DR: In this paper , the authors used spatially resolved transcriptomics to infer spatial copy number variations in 120,000 regions across multiple organs, in benign and malignant tissues, and demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate.
Journal ArticleDOI
Abstract A051: The spatial landscape of clonal somatic copy number alterations in benign and malignant prostate epithelia
Andrew Erickson,Mengxiao He,Emelie Berglund,Maja Marklund,Reza Mirzazadeh,Niklas Schultz,Linda Kvastad,Alma Andersson,Ludvig Bergenstråhle,Joseph Bergenstråhle,Ludvig Larsson,Leire Alonso Galicia,Alia Shamikh,Elisa Basmaci,Teresita Díaz de Ståhl,Timothy Rajakumar,Dimitrios Doultsinos,Kim Thrane,Andrew L. Ji,Paul A. Khavari,Firaz Tarish,Anna Tanoglidi,Jonas Maaskola,Richard Colling,Tuomas Mirtti,Freddie C. Hamdy,Dan J. Woodcock,Thomas Helleday,Ian G. Mills,Alastair D. Lamb,Joakim Lundeberg +30 more
TL;DR: Erickson et al. as discussed by the authors employed spatially resolved transcriptomics (Visium, 10x Genomics) to infer spatial copy number variations in >120 000 spatial regions across multiple organs, tissues and tumors, including three whole axial prostates.
Posted ContentDOI
Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of cancer
Andrew Erickson,Sandy Figiel,Timothy Rajakumar,Srinivasa R. Rao,Wencheng Yin,Dimitrios Doultsinos,Anette L. Magnussen,Reema Singh,Ninu Poulose,Richard J. Bryant,Olivier Cussenot,Freddie C. Hamdy,Dan J. Woodcock,Ian G. Mills,Alastair D. Lamb +14 more
TL;DR: In this paper , the accuracy of inferred-transcript to recapitulate DNA-based tumor phylogenies was evaluated using a comparison of pseudo-bulked spatial transcriptomic data to adjacent sections with WGS data.