J
Joseph Bergenstråhle
Researcher at Royal Institute of Technology
Publications - 23
Citations - 2191
Joseph Bergenstråhle is an academic researcher from Royal Institute of Technology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 17 publications receiving 836 citations. Previous affiliations of Joseph Bergenstråhle include Science for Life Laboratory.
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Journal ArticleDOI
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.
Andrew L. Ji,Adam J. Rubin,Kim Thrane,Sizun Jiang,David Reynolds,Robin M. Meyers,Margaret Guo,Benson M. George,Annelie Mollbrink,Joseph Bergenstråhle,Ludvig Larsson,Yunhao Bai,Bokai Zhu,Aparna Bhaduri,Jordan M. Meyers,Xavier Rovira-Clavé,S. Tyler Hollmig,Sumaira Z. Aasi,Garry P. Nolan,Joakim Lundeberg,Paul A. Khavari,Paul A. Khavari +21 more
TL;DR: To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), single-cell RNA sequencing with spatial transcriptomics and multiplexed ion beam imaging from a series of human cSCCs and matched normal skin were combined.
Journal ArticleDOI
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Emelie Berglund,Jonas Maaskola,Niklas Schultz,Stefanie Friedrich,Maja Marklund,Joseph Bergenstråhle,Firas Tarish,Anna Tanoglidi,Sanja Vickovic,Ludvig Larsson,Fredrik Salmén,Christoph Ogris,Karolina Wallenborg,Jens Lagergren,Patrik L. Ståhl,Erik L. L. Sonnhammer,Thomas Helleday,Joakim Lundeberg +17 more
TL;DR: Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today and here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment.
Journal ArticleDOI
Spatially Resolved Transcriptomes-Next Generation Tools for Tissue Exploration.
TL;DR: In this review, available spatial transcriptomics methods are described and their applications as well as their strengths and weaknesses are discussed.
Posted ContentDOI
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Pascal Barbry,Christoph Muus,Christoph Muus,Malte D Luecken,Gökcen Eraslan,Avinash Waghray,Graham Heimberg,Lisa Sikkema,Yoshihiko Kobayashi,Eeshit Dhaval Vaishnav,Ayshwarya Subramanian,Christopher Smilie,Karthik A. Jagadeesh,Elizabeth Thu Duong,Evgenij Fiskin,Elena Torlai Triglia,Meshal Ansari,Peiwen Cai,Brian M. Lin,Justin Buchanan,Sijia Chen,Jian Shu,Jian Shu,Adam L. Haber,Adam L. Haber,Hattie Chung,Daniel T. Montoro,Taylor Adams,Hananeh Aliee,J. Samuel,Allon Zaneta Andrusivova,Ilias Angelidis,Orr Ashenberg,Kevin Bassler,Christophe Bécavin,Inbal Benhar,Joseph Bergenstråhle,Ludvig Bergenstråhle,Liam Bolt,Emelie Braun,Linh T. Bui,Mark Chaffin,Evgeny Chichelnitskiy,Joshua Chiou,Thomas M. Conlon,Michael S. Cuoco,Marie Deprez,David Fischer,Astrid Gillich,Joshua Gould,Minzhe Guo,Austin J. Gutierrez,Arun C. Habermann,Tyler Harvey,Peng He,Xiaomeng Hou,Xiaomeng Hou,Lijuan Hu,Alok Jaiswal,Peiyong Jiang,Theodoros Kapellos,Christin S. Kuo,Ludvig Larsson,Michael Leney-Greene,Kyungtae Lim,Monika Litviňuková,Monika Litviňuková,Ji Lu,Leif S. Ludwig,Wendy Luo,Henrike Maatz,Elo Madissoon,Lira Mamanova,Kasidet Manakongtreecheep,Kasidet Manakongtreecheep,Charles-Hugo Marquette,Ian Mbano,Alexi McAdams,Ross J. Metzger,Ahmad N. Nabhan,Sarah K. Nyquist,Lolita Penland,Olivier Poirion,Sergio Poli,Cancan Qi,Rachel Queen,Daniel Reichart,Daniel Reichart,Ivan O. Rosas,Jonas C. Schupp,Rahul Sinha,Rene Sit,Kamil Slowikowski,Kamil Slowikowski,Michal Slyper,Neal Smith,Neal Smith,Alex Sountoulidis,Maximilian Strunz,Dawei Sun,Carlos Talavera-López,Peng Tan,Jessica Tantivit,Jessica Tantivit,Kyle J. Travaglini,Nathan R. Tucker,Katherine A. Vernon,Katherine A. Vernon,Marc Wadsworth,Julia Waldman,Xiuting Wang,Wenjun Yan,William Zhao,Carly Ziegler +113 more
TL;DR: Differences in the cell type-specific expression of mediators of SARS-CoV-2 viral entry may be responsible for aspects of COVID-19 epidemiology and clinical course, and point to putative molecular pathways involved in disease susceptibility and pathogenesis.
Journal ArticleDOI
Single-cell and spatial transcriptomics enables probabilistic inference of cell type topography.
Alma Andersson,Joseph Bergenstråhle,Michaela Asp,Ludvig Bergenstråhle,Aleksandra Jurek,José Fernández Navarro,Joakim Lundeberg +6 more
TL;DR: A probabilistic framework is presented that integrates single-cell and bulk spatial transcriptomics in order to spatially map cell types onto their respective tissues and applies to the developing human heart and mouse brain to demonstrate the power of the technique.