A
Andrew Erickson
Researcher at University of Oxford
Publications - 43
Citations - 348
Andrew Erickson is an academic researcher from University of Oxford. The author has contributed to research in topics: Prostate cancer & Medicine. The author has an hindex of 7, co-authored 31 publications receiving 177 citations. Previous affiliations of Andrew Erickson include University of Helsinki.
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Journal ArticleDOI
Spatially resolved clonal copy number alterations in benign and malignant tissue
Andrew Erickson,Mengxiao He,Emelie Berglund,Maja Marklund,Reza Mirzazadeh,Niklas Schultz,Linda Kvastad,Alma Andersson,Ludvig Bergenstråhle,Joseph Bergenstråhle,Ludvig Larsson,Leire Alonso Galicia,Alia Shamikh,Elisa Basmaci,Teresita Díaz de Ståhl,Timothy Rajakumar,Dimitrios Doultsinos,Kim Thrane,Andrew L. Ji,Paul A. Khavari,Firaz Tarish,Anna Tanoglidi,Jonas Maaskola,Richard Colling,Tuomas Mirtti,Freddie C. Hamdy,Dan J. Woodcock,Thomas Helleday,Ian G. Mills,Alastair D. Lamb,Joakim Lundeberg +30 more
TL;DR: In this paper , the authors used spatially resolved transcriptomics to infer spatial copy number variations in 120,000 regions across multiple organs, in benign and malignant tissues, and demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate.
Journal ArticleDOI
PTEN Loss but Not ERG Expression in Diagnostic Biopsies Is Associated with Increased Risk of Progression and Adverse Surgical Findings in Men with Prostate Cancer on Active Surveillance
TL;DR: PTEN status at diagnosis is a potential biomarker for identifying patients with PCa on AS with a high risk for progression or adverse findings on subsequent RP, and a simple diagnostic biopsy-based analysis of PTEN status may help identify patients with highrisk for prostate cancer progression.
Journal ArticleDOI
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse.
Sinja Taavitsainen,Nikolai Engedal,Shaolong Cao,Florian Handle,Florian Handle,Andrew Erickson,Stefan Prekovic,Daniel Wetterskog,Teemu Tolonen,Elisa M. Vuorinen,A. Kiviaho,Reetta Nätkin,Tomi Häkkinen,Wout Devlies,S. Henttinen,Roosa Kaarijärvi,Mari Lahnalampi,Heidi Kaljunen,K. Nowakowska,Heimo Syvälä,Merja Bläuer,Paolo Cremaschi,Frank Claessens,Tapio Visakorpi,Teuvo L.J. Tammela,Teemu J. Murtola,Kirsi J. Granberg,Alastair D. Lamb,Alastair D. Lamb,Kirsi Ketola,Ian G. Mills,Ian G. Mills,Ian G. Mills,G. Attard,Wei Lien Wang,Matti Nykter,Alfonso Urbanucci +36 more
TL;DR: In this article, single-cell assays for transposase-accessible chromatin (ATAC) and RNA sequencing in models of early treatment response and resistance to enzalutamide were employed to identify pre-existing and treatment-persistent cell subpopulations that possess regenerative potential when subjected to treatment.
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Loss of PTEN expression in ERG-negative prostate cancer predicts secondary therapies and leads to shorter disease-specific survival time after radical prostatectomy
Kanerva Lahdensuo,Andrew Erickson,Irena Saarinen,Heikki Seikkula,Johan Lundin,Mikael Lundin,Stig Nordling,Anna Bützow,Hanna Vasarainen,Peter J. Boström,Pekka Taimen,Antti Rannikko,Tuomas Mirtti +12 more
TL;DR: Assessment of PTEN and ERG status could provide an additional tool for initial diagnostics when determining the prognosis and subsequent follow-up regimen for patients treated by radical prostatectomy.
Journal ArticleDOI
Fibroblast as a critical stromal cell type determining prognosis in prostate cancer.
Sami Blom,Andrew Erickson,Arne Östman,Antti Rannikko,Tuomas Mirtti,Olli Kallioniemi,Olli Kallioniemi,Teijo Pellinen +7 more
TL;DR: Tumor stroma associates with prostate cancer (PCa) progression, but its specific cellular composition and association to patient survival outcome have not been characterized.