A
Alastair D. Lamb
Researcher at University of Oxford
Publications - 116
Citations - 2931
Alastair D. Lamb is an academic researcher from University of Oxford. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 24, co-authored 96 publications receiving 2119 citations. Previous affiliations of Alastair D. Lamb include Peterborough City Hospital & Churchill Hospital.
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Journal ArticleDOI
The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man
N L Sharma,Charles E. Massie,Antonio Ramos-Montoya,Vincent Zecchini,H Scott,Alastair D. Lamb,Stewart MacArthur,Rory Stark,Anne Y. Warren,Ian G. Mills,David E. Neal +10 more
TL;DR: A 16 gene signature that outperformed a larger in-vitro-derived signature in clinical data sets is identified, showing the importance of persistent AR signaling in CRPC.
Journal ArticleDOI
Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study
Emilie Lalonde,Emilie Lalonde,Adrian Ishkanian,Jenna Sykes,Michael Fraser,Michael Fraser,Helen Ross-Adams,Nicholas Erho,Mark J Dunning,Silvia Halim,Alastair D. Lamb,Nathalie C. Moon,Gaetano Zafarana,Gaetano Zafarana,Anne Y. Warren,Xianyue Meng,John Thoms,John Thoms,Michal R. Grzadkowski,Alejandro Berlin,Alejandro Berlin,Cherry Have,Varune Rohan Ramnarine,Varune Rohan Ramnarine,Varune Rohan Ramnarine,CQ Yao,CQ Yao,Chad A. Malloff,Lucia L. Lam,Honglei Xie,Nicholas J. Harding,Denise Y.F. Mak,Kenneth C. Chu,Kenneth C. Chu,Lauren C. Chong,Dorota H. Sendorek,Christine P'ng,Colin Collins,Jeremy A. Squire,Igor Jurisica,Igor Jurisica,Colin Cooper,Colin Cooper,Rosalind A. Eeles,Rosalind A. Eeles,Melania Pintilie,Alan Dal Pra,Alan Dal Pra,Alan Dal Pra,Elai Davicioni,Wan L. Lam,Michael Milosevic,David E. Neal,Theodorus van der Kwast,Theodorus van der Kwast,Paul C. Boutros,Robert G. Bristow,Robert G. Bristow +57 more
TL;DR: This is the first study of cancer outcome to integrate DNA-based and microenvironment-based failure indices to predict patient outcome and identifies low-risk to high-risk patients who are most likely to fail treatment within 18 months.
Journal ArticleDOI
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study
Helen Ross-Adams,Alastair D. Lamb,Mark J Dunning,Silvia Halim,Johan Lindberg,C M Massie,Lars Egevad,Roslin Russell,Antonio Ramos-Montoya,Sarah L. Vowler,N L Sharma,Jonathan Kay,Hayley C. Whitaker,Jeremy Clark,Rachel Hurst,Vincent J. Gnanapragasam,Nimish Shah,Anne Y. Warren,Cyrus Cooper,Andy G. Lynch,Rory Stark,Ian G. Mills,Henrik Grönberg,David E. Neal +23 more
TL;DR: For the first time in prostate cancer this study demonstrates the importance of integrated genomic analyses incorporating both benign and tumour tissue data in identifying molecular alterations leading to the generation of robust gene sets that are predictive of clinical outcome in independent patient cohorts.
Journal ArticleDOI
Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.
Mohammad Asim,Charles E. Massie,Folake A Orafidiya,Nelma Pértega-Gomes,Anne Y. Warren,Mohsen Esmaeili,Luke A. Selth,Heather I. Zecchini,Katarina Luko,Arham Qureshi,Ajoeb Baridi,Suraj Menon,Basetti Madhu,Carlos Escriu,Scott K. Lyons,Sarah L. Vowler,Vincent Zecchini,Greg Shaw,Wiebke Hessenkemper,Roslin Russell,Hisham Mohammed,Niki Stefanos,Andy G. Lynch,Elena Grigorenko,Clive D'Santos,Chris Taylor,Alastair D. Lamb,Rouchelle Sriranjan,Jiali Yang,Rory Stark,Scott M. Dehm,Paul S. Rennie,Jason S. Carroll,John R. Griffiths,Simon Tavaré,Ian G. Mills,Ian G. Mills,Iain J. McEwan,Aria Baniahmad,Wayne D. Tilley,David E. Neal +40 more
TL;DR: CHKA is the first kinase identified as an AR chaperone, providing, to the authors' knowledge, the first evidence for kinases as molecular chaperones, making CHKA both a marker of tumor progression and a potential therapeutic target for PCa.
Journal ArticleDOI
Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in the Detection of Clinically Significant Prostate Cancer in the Prostate Imaging Reporting and Data System Era: A Systematic Review and Meta-analysis.
Niranjan J. Sathianathen,Niranjan J. Sathianathen,Altan Omer,Eli Harriss,Lucy Davies,Veeru Kasivisvanathan,Shonit Punwani,Caroline M. Moore,Christof Kastner,Tristan Barrett,Roderick C.N. van den Bergh,Ben Eddy,Fergus V. Gleeson,Ruth MacPherson,Richard J. Bryant,James W.F. Catto,Declan G. Murphy,Freddie C. Hamdy,Hashim U. Ahmed,Alastair D. Lamb +19 more
TL;DR: Multiparametric MRI of the prostate is generally an accurate test for ruling out csPCa, however, heterogeneity in the NPV estimates is observed, and local institutional data should form the basis of decision making if available.