Ruthenium(II)-Catalyzed C-C/C-N Coupling of 2-Arylquinazolinones with Vinylene Carbonate: Access to Fused Quinazolinones.

A rhodium(III)-catalyzed formal C–H [5 + 1] cyclization of 2-pyrrolyl/indolylanilines with vinylene carbonate has been explored towards the potent assembly of diverse 4-methylpyrrolo[1,2-a]quinoxalines. This established protocol is characterized by an exceedingly simple reaction system, and excellent functional group toleration and yields. Most importantly, entirely distinct from documented [4 + 2] cyclization conversions, herein, the emerging vinylene carbonate firstly presents as a C1 synthon to realize [5 + 1] annulation and shows new chemical reactivity. Biological studies indicate that these prepared products are promising candidates in terms of their antibacterial activity.

RhIII-Catalyzed formal [5 + 1] cyclization of 2-pyrrolyl/indolylanilines using vinylene carbonate as a C1 synthon

C–H bond functionalization by high-valent cobalt catalysis: current progress, challenges and future perspectives

Vinylene carbonate: beyond the ethyne surrogate in rhodium-catalyzed annulation with amidines toward 4-methylquinazolines

Rhodium-Catalyzed Dehydrogenative Annulation of N-Arylmethanimines with Vinylene Carbonate for Synthesizing Quinolines.

Co(III)-Catalyzed Annulative Vinylene Transfer via C–H Activation: Three-Step Total Synthesis of 8-Oxopseudopalmatine and Oxopalmatine

The Rh(III)-catalyzed synthesis of spiroquinoxalinone derivatives from 3-arylquinoxalin-2(1H)-ones and alkynes via a C–H functionalization/[3 + 2] annulation sequence has been developed. This method, featuring low catalyst loading, was amenable to Gram scale synthesis and tolerated a variety of functional groups and substitution patterns on the aryl rings, providing the target products in good to excellent yields.

/pdf/rh-iii-catalyzed-spiroannulation-of-3-arylquinoxalin-2-1h-4nhuzp7n97.pdf

Ting Huang

Papers

Co(III)-Catalyzed Annulative Vinylene Transfer via C–H Activation: Three-Step Total Synthesis of 8-Oxopseudopalmatine and Oxopalmatine

Rh(III)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones