T
Tinglin Pu
Researcher at Nanjing Medical University
Publications - 5
Citations - 588
Tinglin Pu is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Glymphatic system & Aquaporin 4. The author has an hindex of 4, co-authored 5 publications receiving 271 citations.
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Journal ArticleDOI
Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Humberto Mestre,Lauren M. Hablitz,Anna L.R. Xavier,Weixi Feng,Wenyan Zou,Tinglin Pu,Hiromu Monai,Giridhar Murlidharan,Ruth M. Castellanos Rivera,Matthew J. Simon,Martin M. Pike,Virginia Plá,Ting Du,Benjamin T. Kress,Xiaowen Wang,Benjamin A. Plog,Alexander S. Thrane,Alexander S. Thrane,Iben Lundgaard,Iben Lundgaard,Yoichiro Abe,Masato Yasui,John H. Thomas,Ming Xiao,Hajime Hirase,Aravind Asokan,Aravind Asokan,Jeffrey J. Iliff +27 more
TL;DR: It is concur that CSF influx is higher in wild-type mice than in four different Aqp4 KO lines and in one line that lacks perivascular AQP4 (Snta1 KO), and it is reported that intrastriatal injections suppress glymphatic function.
Journal ArticleDOI
Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
TL;DR: The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology.
Journal ArticleDOI
Persistent Malfunction of Glymphatic and Meningeal Lymphatic Drainage in a Mouse Model of Subarachnoid Hemorrhage.
TL;DR: Persistent malfunction of glymphatic and meningeal lymphatic drainage and related neuropathological damages after SAH are demonstrated.
Posted ContentDOI
Aquaporin-4 dependent glymphatic solute transport in rodent brain
Humberto Mestre,Benjamin T. Kress,Wenyan Zou,Tinglin Pu,Giridhar Murlidharan,Ruth M. Castellanos Rivera,Matthew J. Simon,Martin M. Pike,Benjamin A. Plog,Anna L.R. Xavier,Alexander S. Thrane,Iben Lundgaard,John H. Thomas,Ming Xiao,Aravind Asokan,Jeffrey J. Iliff +15 more
TL;DR: CSF tracer influx, as well as fluorescently-tagged amyloid-β efflux, are significantly faster in wild-type mice than in three different transgenic lines featuring disruption of the Aqp4 gene and one line in which AQP4 expression lacks the critical perivascular localization (Snta1 knockout).
Peer ReviewDOI
Author response: Aquaporin-4-dependent glymphatic solute transport in the rodent brain
Humberto Mestre,Lauren M. Hablitz,Anna Lr Xavier,Weixi Feng,Wenyan Zou,Tinglin Pu,Hiromu Monai,Giridhar Murlidharan,Ruth M. Castellanos Rivera,Matthew J. Simon,Martin M. Pike,Virginia Plá,Ting Du,Benjamin T. Kress,Xiaowen Wang,Benjamin A. Plog,Alexander S. Thrane,Alexander S. Thrane,Iben Lundgaard,Iben Lundgaard,Yoichiro Abe,Masato Yasui,John H. Thomas,Ming Xiao,Hajime Hirase,Aravind Asokan,Aravind Asokan,Jeffrey J. Iliff +27 more