T
Tino D. Piscione
Researcher at University of Toronto
Publications - 23
Citations - 1736
Tino D. Piscione is an academic researcher from University of Toronto. The author has contributed to research in topics: Kidney & Phosphorylation. The author has an hindex of 17, co-authored 23 publications receiving 1514 citations. Previous affiliations of Tino D. Piscione include Hospital for Sick Children.
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Journal ArticleDOI
Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test.
Anath C. Lionel,Gregory Costain,Nasim Monfared,Susan Walker,Miriam S. Reuter,S. Mohsen Hosseini,Bhooma Thiruvahindrapuram,Daniele Merico,Rebekah Jobling,Thomas Nalpathamkalam,Giovanna Pellecchia,Wilson W L Sung,Zhuozhi Wang,Peter Bikangaga,Cyrus Boelman,Melissa T. Carter,Dawn Cordeiro,Cheryl Cytrynbaum,Sharon D. Dell,Priya Dhir,James J. Dowling,Elise Heon,Stacy Hewson,Linda T. Hiraki,Michal Inbar-Feigenberg,Regan Klatt,Regan Klatt,Jonathan B. Kronick,Ronald M. Laxer,Christoph Licht,Heather MacDonald,Heather MacDonald,Saadet Mercimek-Andrews,Roberto Mendoza-Londono,Tino D. Piscione,Rayfel Schneider,Andreas Schulze,Earl D. Silverman,Komudi Siriwardena,O. Carter Snead,Neal Sondheimer,Joanne Sutherland,Ajoy Vincent,Jonathan D. Wasserman,Rosanna Weksberg,Cheryl Shuman,Chris Carew,Michael J. Szego,Robin Z. Hayeems,Raveen K. Basran,Dimitri J. Stavropoulos,Peter N. Ray,Sarah Bowdin,M. Stephen Meyn,Ronald D. Cohn,Stephen W. Scherer,Christian R. Marshall +56 more
TL;DR: WGS as a primary clinical test provided a higher diagnostic yield than conventional genetic testing in a clinically heterogeneous cohort and confirmed recent disease associations with the genes PIGG, RNU4ATAC, TRIO, and UNC13A.
Journal ArticleDOI
Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome
Danielle F. Cano-Gauci,Danielle F. Cano-Gauci,Howard H. Song,Howard H. Song,Huiling Yang,Huiling Yang,Colin McKerlie,Barbara Choo,Barbara Choo,Wen Shi,Wen Shi,Rose Pullano,Rose Pullano,Tino D. Piscione,Silviu Grisaru,Shawn Soon,Larisa Sedlackova,A. Keith Tanswell,Tak W. Mak,Tak W. Mak,Herman Yeger,Gina Lockwood,Gina Lockwood,Norman D. Rosenblum,Jorge Filmus,Jorge Filmus +25 more
TL;DR: It is reported that GPC3-deficient mice exhibit several of the clinical features observed in SGBS patients, including developmental overgrowth, perinatal death, cystic and dyplastic kidneys, and abnormal lung development.
Journal ArticleDOI
BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis.
Tino D. Piscione,Thomas D. Yager,Indra Gupta,Branko Grinfeld,York Pei,Liliana Attisano,Jeffrey L. Wrana,Norman D. Rosenblum +7 more
TL;DR: OP-1 and BMP-2 directly control branching morphogenesis and that the effects of OP-1 are dependent on its local concentration within developing kidney tissue, which is concluded to be stimulatory and inhibitory.
Journal ArticleDOI
Ectopic Notch Activation in Developing Podocytes Causes Glomerulosclerosis
Aoife M. Waters,Megan Y.J. Wu,Tuncer Onay,Jacob Scutaru,Ju Liu,Corrinne G. Lobe,Susan E. Quaggin,Tino D. Piscione +7 more
TL;DR: The results suggest that Notch signaling is dispensable during terminal differentiation of podocytes but that constitutive (or inappropriate) NotCh signaling is deleterious, leading to glomerulosclerosis.
Journal ArticleDOI
BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways.
TL;DR: It is concluded that BMP7 exerts dose-dependent effects on ureteric bud or collecting duct cell proliferation and apoptosis by signaling via Smad 1-dependent and Smad1-independent pathways.