H
Heather MacDonald
Researcher at Carleton University
Publications - 72
Citations - 3495
Heather MacDonald is an academic researcher from Carleton University. The author has contributed to research in topics: Medicine & Telerehabilitation. The author has an hindex of 27, co-authored 64 publications receiving 2529 citations. Previous affiliations of Heather MacDonald include St. Michael's GAA, Sligo & St. Michael's Hospital.
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Journal ArticleDOI
Comparisons of Interventions for Preventing Falls in Older Adults: A Systematic Review and Meta-analysis.
Andrea C. Tricco,Andrea C. Tricco,Sonia M. Thomas,Areti Angeliki Veroniki,Jemila S. Hamid,Elise Cogo,Lisa Strifler,Lisa Strifler,Paul A. Khan,Reid Robson,Kathryn M. Sibley,Kathryn M. Sibley,Heather MacDonald,John J. Riva,Kednapa Thavorn,Kednapa Thavorn,Charlotte Wilson,Jayna Holroyd-Leduc,Gillian D. Kerr,Fabio Feldman,Sumit R. Majumdar,Susan B. Jaglal,Wing Hui,Sharon E. Straus,Sharon E. Straus +24 more
TL;DR: Exercise alone and various combinations of interventions were associated with lower risk of injurious falls compared with usual care, and choice of fall-prevention intervention may depend on patient and caregiver values and preferences.
Journal ArticleDOI
Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test.
Anath C. Lionel,Gregory Costain,Nasim Monfared,Susan Walker,Miriam S. Reuter,S. Mohsen Hosseini,Bhooma Thiruvahindrapuram,Daniele Merico,Rebekah Jobling,Thomas Nalpathamkalam,Giovanna Pellecchia,Wilson W L Sung,Zhuozhi Wang,Peter Bikangaga,Cyrus Boelman,Melissa T. Carter,Dawn Cordeiro,Cheryl Cytrynbaum,Sharon D. Dell,Priya Dhir,James J. Dowling,Elise Heon,Stacy Hewson,Linda T. Hiraki,Michal Inbar-Feigenberg,Regan Klatt,Regan Klatt,Jonathan B. Kronick,Ronald M. Laxer,Christoph Licht,Heather MacDonald,Heather MacDonald,Saadet Mercimek-Andrews,Roberto Mendoza-Londono,Tino D. Piscione,Rayfel Schneider,Andreas Schulze,Earl D. Silverman,Komudi Siriwardena,O. Carter Snead,Neal Sondheimer,Joanne Sutherland,Ajoy Vincent,Jonathan D. Wasserman,Rosanna Weksberg,Cheryl Shuman,Chris Carew,Michael J. Szego,Robin Z. Hayeems,Raveen K. Basran,Dimitri J. Stavropoulos,Peter N. Ray,Sarah Bowdin,M. Stephen Meyn,Ronald D. Cohn,Stephen W. Scherer,Christian R. Marshall +56 more
TL;DR: WGS as a primary clinical test provided a higher diagnostic yield than conventional genetic testing in a clinically heterogeneous cohort and confirmed recent disease associations with the genes PIGG, RNU4ATAC, TRIO, and UNC13A.
Journal ArticleDOI
Whole-genome sequencing expands diagnostic utility and improves clinical management in paediatric medicine
Dimitri J. Stavropoulos,Daniele Merico,Rebekah Jobling,Sarah Bowdin,Nasim Monfared,Bhooma Thiruvahindrapuram,Thomas Nalpathamkalam,Giovanna Pellecchia,Ryan K. C. Yuen,Michael J. Szego,Michael J. Szego,Robin Z. Hayeems,Randi Zlotnik Shaul,Michael Brudno,Marta Girdea,Brendan J. Frey,Babak Alipanahi,Sohnee Ahmed,Riyana Babul-Hirji,Ramses Badilla Porras,Melissa T. Carter,Lauren Chad,Ayeshah Chaudhry,David Chitayat,David Chitayat,Soghra Jougheh Doust,Cheryl Cytrynbaum,Lucie Dupuis,Resham Ejaz,Leona Fishman,Andrea Guerin,Bita Hashemi,Mayada Helal,Stacy Hewson,Michal Inbar-Feigenberg,Peter Kannu,Natalya Karp,Raymond H. Kim,Jonathan B. Kronick,Eriskay Liston,Heather MacDonald,Saadet Mercimek-Mahmutoglu,Roberto Mendoza-Londono,Enas Nasr,Graeme A. M. Nimmo,Nicole Parkinson,Nada Quercia,Julian Raiman,Maian Roifman,Andreas Schulze,Andrea Shugar,Cheryl Shuman,Pierre Sinajon,Komudi Siriwardena,Rosanna Weksberg,Grace Yoon,Chris Carew,Raith Erickson,Richard A. Leach,Robert Klein,Peter N. Ray,M. Stephen Meyn,Stephen W. Scherer,Ronald D. Cohn,Christian R. Marshall +64 more
TL;DR: Clinical implementation of WGS as a primary test will provide a higher diagnostic yield than conventional genetic testing and potentially reduce the time required to reach a genetic diagnosis.
Journal ArticleDOI
The Necdin Gene is Deleted in Prader-Willi Syndrome and is Imprinted in Human and Mouse
Heather MacDonald,Rachel Wevrick +1 more
TL;DR: It is reported that the human necdin-encoding gene (NDN) is within the centromeric portion of the PWS deletion region, between the two imprinted genes ZNF127 and SNRPN, and demonstrated that expression of Ndn is limited to the paternal allele in RNA from newborn mouse brain.
Journal ArticleDOI
Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes
Areti Angeliki Veroniki,Elise Cogo,Patricia Rios,Sharon E. Straus,Sharon E. Straus,Yaron Finkelstein,Yaron Finkelstein,Ryan Kealey,Emily Reynen,Charlene Soobiah,Charlene Soobiah,Kednapa Thavorn,Kednapa Thavorn,Kednapa Thavorn,Brian Hutton,Brian Hutton,Brenda R. Hemmelgarn,Fatemeh Yazdi,Jennifer D'Souza,Heather MacDonald,Andrea C. Tricco,Andrea C. Tricco +21 more
TL;DR: The newer generation AEDs, lamotrigine and levetiracetam, were not associated with significant increased risks of CMs compared to control, and were significantly less likely to be associated with children experiencing cardiac malformations than control.