S
S. Mohsen Hosseini
Researcher at University of Toronto
Publications - 26
Citations - 2628
S. Mohsen Hosseini is an academic researcher from University of Toronto. The author has contributed to research in topics: Genome-wide association study & Type 1 diabetes. The author has an hindex of 21, co-authored 23 publications receiving 2176 citations. Previous affiliations of S. Mohsen Hosseini include Hospital for Sick Children & George Washington University.
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Journal ArticleDOI
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
Virginie J. M. Verhoeven,Pirro G. Hysi,Robert Wojciechowski,Robert Wojciechowski,Qiao Fan,Jeremy A. Guggenheim,René Höhn,Stuart MacGregor,Alex W. Hewitt,Alex W. Hewitt,Abhishek Nag,Ching-Yu Cheng,Ching-Yu Cheng,Ekaterina Yonova-Doing,Xin Zhou,M. Kamran Ikram,M. Kamran Ikram,Gabriëlle H.S. Buitendijk,George McMahon,John P. Kemp,Beate St Pourcain,Claire L. Simpson,Kari-Matti Mäkelä,Terho Lehtimäki,Mika Kähönen,Andrew D. Paterson,S. Mohsen Hosseini,Hoi Suen Wong,Liang Xu,Jost B. Jonas,Olavi Pärssinen,Juho Wedenoja,Shea Ping Yip,Daniel W.H. Ho,Daniel W.H. Ho,Chi Pui Pang,Li Jia Chen,Kathryn P. Burdon,Jamie E Craig,Barbara E.K. Klein,Ronald Klein,Toomas Haller,Andres Metspalu,Chiea Chuen Khor,Chiea Chuen Khor,E-Shyong Tai,Tin Aung,Tin Aung,Eranga N. Vithana,Wan Ting Tay,Veluchamy A. Barathi,Veluchamy A. Barathi,Myopia (Cream),Peng Chen,Ruoying Li,Jiemin Liao,Yingfeng Zheng,Rick Twee-Hee Ong,Angela Döring,Complications Trial,Complications (Dcct),David M. Evans,Nicholas J. Timpson,Annemieke J.M.H. Verkerk,Thomas Meitinger,Olli T. Raitakari,Felicia Hawthorne,Tim D. Spector,Lennart C. Karssen,Mario Pirastu,Federico Murgia,Wei Ang,Aniket Mishra,Grant W. Montgomery,Craig E. Pennell,Phillippa M. Cumberland,Ioana Cotlarciuc,Paul Mitchell,Jie Jin Wang,Jie Jin Wang,Maria Schache,Sarayut Janmahasatian,Robert P. Igo,Jonathan H. Lass,Emily Y. Chew,Sudha K. Iyengar,Theo G. M. F. Gorgels,Igor Rudan,Caroline Hayward,Alan F. Wright,Ozren Polasek,Zoran Vatavuk,James F. Wilson,Brian W Fleck,Tanja Zeller,Alireza Mirshahi,Christian P. Müller,André G. Uitterlinden,Fernando Rivadeneira,Johannes R. Vingerling,Albert Hofman,Ben A. Oostra,Najaf Amin,Arthur A.B. Bergen,Yik Ying Teo,Jugnoo S Rahi,Jugnoo S Rahi,Jugnoo S Rahi,Veronique Vitart,Cathy Williams,Paul N. Baird,Tien Yin Wong,Tien Yin Wong,Konrad Oexle,Norbert Pfeiffer,David A. Mackey,David A. Mackey,Terri L. Young,Cornelia M. van Duijn,Seang-Mei Saw,Seang-Mei Saw,Seang-Mei Saw,Joan E. Bailey-Wilson,Joan E. Bailey-Wilson,Dwight Stambolian,Caroline C W Klaver,Caroline C W Klaver,Christopher J Hammond,Christopher J Hammond +128 more
TL;DR: The CREAM consortium conducted genome-wide meta-analyses, which identified 16 new loci for refractive error in individuals of European ancestry and 8 were shared with Asians, and identified 8 additional associated loci.
Journal ArticleDOI
Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test.
Anath C. Lionel,Gregory Costain,Nasim Monfared,Susan Walker,Miriam S. Reuter,S. Mohsen Hosseini,Bhooma Thiruvahindrapuram,Daniele Merico,Rebekah Jobling,Thomas Nalpathamkalam,Giovanna Pellecchia,Wilson W L Sung,Zhuozhi Wang,Peter Bikangaga,Cyrus Boelman,Melissa T. Carter,Dawn Cordeiro,Cheryl Cytrynbaum,Sharon D. Dell,Priya Dhir,James J. Dowling,Elise Heon,Stacy Hewson,Linda T. Hiraki,Michal Inbar-Feigenberg,Regan Klatt,Regan Klatt,Jonathan B. Kronick,Ronald M. Laxer,Christoph Licht,Heather MacDonald,Heather MacDonald,Saadet Mercimek-Andrews,Roberto Mendoza-Londono,Tino D. Piscione,Rayfel Schneider,Andreas Schulze,Earl D. Silverman,Komudi Siriwardena,O. Carter Snead,Neal Sondheimer,Joanne Sutherland,Ajoy Vincent,Jonathan D. Wasserman,Rosanna Weksberg,Cheryl Shuman,Chris Carew,Michael J. Szego,Robin Z. Hayeems,Raveen K. Basran,Dimitri J. Stavropoulos,Peter N. Ray,Sarah Bowdin,M. Stephen Meyn,Ronald D. Cohn,Stephen W. Scherer,Christian R. Marshall +56 more
TL;DR: WGS as a primary clinical test provided a higher diagnostic yield than conventional genetic testing in a clinically heterogeneous cohort and confirmed recent disease associations with the genes PIGG, RNU4ATAC, TRIO, and UNC13A.
Journal ArticleDOI
Reappraisal of Reported Genes for Sudden Arrhythmic Death: Evidence-Based Evaluation of Gene Validity for Brugada Syndrome.
S. Mohsen Hosseini,Raymond H. Kim,Sharmila Udupa,Gregory Costain,Rebekah Jobling,Eriskay Liston,Seema M. Jamal,Marta Szybowska,Chantal F. Morel,Sarah Bowdin,John Garcia,Melanie Care,Amy C. Sturm,Valeria Novelli,Michael J. Ackerman,James S. Ware,Ray E. Hershberger,Arthur A.M. Wilde,Michael H. Gollob +18 more
TL;DR: The results contest the clinical validity of all but 1 gene clinically tested and reported to be associated with BrS, and warrant a systematic, evidence-based evaluation for reported gene-disease associations before use in patient care.
Journal ArticleDOI
New susceptibility loci associated with kidney disease in type 1 diabetes.
Niina Sandholm,Niina Sandholm,Rany M. Salem,Rany M. Salem,Amy Jayne McKnight,Eoin P. Brennan,Carol Forsblom,Tamara Isakova,Gareth J. McKay,Winfred W. Williams,Denise M. Sadlier,Ville-Petteri Mäkinen,Ville-Petteri Mäkinen,Elizabeth Swan,Cameron D. Palmer,Cameron D. Palmer,Andrew P. Boright,Emma Ahlqvist,Harshal Deshmukh,Benjamin J. Keller,Huateng Huang,Aila J. Ahola,Emma Fagerholm,Daniel Gordin,Valma Harjutsalo,Valma Harjutsalo,Bing He,Outi Heikkilä,Kustaa Hietala,Janne P. Kytö,Päivi Lahermo,Markku Lehto,Raija Lithovius,Anne-May Österholm,Maija Parkkonen,Janne Pitkäniemi,Milla Rosengård-Bärlund,Markku Saraheimo,Cinzia Sarti,Jenny Söderlund,Aino Soro-Paavonen,Anna Syreeni,Lena M. Thorn,Heikki O. Tikkanen,Nina Tolonen,Karl Tryggvason,Jaakko Tuomilehto,Johan Wadén,Geoffrey V. Gill,Sarah L. Prior,Candace Guiducci,Daniel B. Mirel,Andrew M. Taylor,Andrew M. Taylor,S. Mohsen Hosseini,Hans-Henrik Parving,Hans-Henrik Parving,Peter Rossing,Peter Rossing,Lise Tarnow,Lise Tarnow,Claes Ladenvall,François Alhenc-Gelas,Pierre Lefebvre,Vincent Rigalleau,Ronan Roussel,David-Alexandre Trégouët,Anna Maestroni,Silvia Maestroni,Henrik Falhammar,Tianwei Gu,Anna Möllsten,D. Cimponeriu,Mihai Ioana,Maria Mota,Eugen Mota,Cristian Serafinceanu,Monica Stavarachi,Robert L. Hanson,Robert G. Nelson,Matthias Kretzler,Helen M. Colhoun,Nicolae Mircea Panduru,Harvest F. Gu,Kerstin Brismar,Gianpaolo Zerbini,Samy Hadjadj,Michel Marre,Michel Marre,Leif Groop,Maria Lajer,Shelley B. Bull,Daryl Waggott,Andrew D. Paterson,David A. Savage,Stephen C. Bain,Finian Martin,Joel N. Hirschhorn,Joel N. Hirschhorn,Catherine Godson,Jose C. Florez,Jose C. Florez,Per-Henrik Groop,Per-Henrik Groop,Alexander P. Maxwell,Alexander P. Maxwell +105 more
TL;DR: A meta-analysis of genome-wide association studies of T1D DN revealed association of two SNPs with ESRD in the AFF3 gene and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, which represent new signals in the pathogenesis of DN.
Journal ArticleDOI
Genome-Wide Association Identifies the ABO Blood Group as a Major Locus Associated With Serum Levels of Soluble E-Selectin
Andrew D. Paterson,Maria F. Lopes-Virella,Daryl Waggott,Andrew P. Boright,S. Mohsen Hosseini,Rickey E. Carter,Enqing Shen,Lucia Mirea,Lucia Mirea,Bhupinder Bharaj,Lei Sun,Shelley B. Bull,Shelley B. Bull +12 more
TL;DR: ABO is a major locus for serum soluble E-selectin levels and analysis of subgroups of A alleles reveals heterogeneity in the association, and even after this was accounted for, an intron 1 SNP remained significantly associated.