R
Ronald D. Cohn
Researcher at Johns Hopkins University School of Medicine
Publications - 87
Citations - 9225
Ronald D. Cohn is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Skeletal muscle & Muscular dystrophy. The author has an hindex of 36, co-authored 79 publications receiving 8374 citations. Previous affiliations of Ronald D. Cohn include Johns Hopkins University & Roy J. and Lucille A. Carver College of Medicine.
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Journal ArticleDOI
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Jennifer P Habashi,Daniel P. Judge,Tammy M. Holm,Ronald D. Cohn,Bart Loeys,Timothy K. Cooper,Loretha Myers,Erin C Klein,Guosheng Liu,Carla L. Calvi,Megan Podowski,Enid Neptune,Marc K. Halushka,Djahida Bedja,Kathleen L. Gabrielson,Daniel B. Rifkin,Luca Carta,Francesco Ramirez,David L. Huso,Harry C. Dietz +19 more
TL;DR: Losartan, a drug already in clinical use for hypertension, merits investigation as a therapeutic strategy for patients with Marfan syndrome and has the potential to prevent the major life-threatening manifestation of this disorder.
Journal ArticleDOI
Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies
Daniel E. Michele,Rita Barresi,Motoi Kanagawa,Fumiaki Saito,Ronald D. Cohn,Jakob S. Satz,James Dollar,Ichizo Nishino,Richard I. Kelley,Hannu Somer,Volker Straub,Katherine D. Mathews,Steven A. Moore,Kevin P. Campbell +13 more
TL;DR: The results suggest that at least three distinct mammalian genes function within a convergent post-translational processing pathway during the biosynthesis of dystroglycan, and that abnormal dystoglycan–ligand interactions underlie the pathogenic mechanism of muscular dystrophy with brain abnormalities.
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Angiotensin II type 1 receptor blockade attenuates TGF-β–induced failure of muscle regeneration in multiple myopathic states
Ronald D. Cohn,Christel Van Erp,Jennifer P Habashi,Arshia Soleimani,Erin C Klein,Matthew T Lisi,Matthew Gamradt,Colette M. Ap Rhys,Tammy M. Holm,Bart Loeys,Francesco Ramirez,Daniel P. Judge,Christopher W. Ward,Harry C. Dietz +13 more
TL;DR: It is shown that increased TGF-β activity leads to failed muscle regeneration in fibrillin-1–deficient mice and a similar therapeutic response in a dystrophin-deficient mouse model of Duchenne muscular dystrophy.
Journal ArticleDOI
Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy
Steven A. Moore,Fumiaki Saito,Jianguo Chen,Daniel E. Michele,Michael D. Henry,Albee Messing,Ronald D. Cohn,Susan E. Ross-Barta,Steve Westra,Roger A. Williamson,Toshinori Hoshi,Kevin P. Campbell +11 more
TL;DR: The hypothesis that defects in dystroglycan are central to the pathogenesis of structural and functional brain abnormalities seen in CMD is strongly supported.
Journal ArticleDOI
Molecular basis of muscular dystrophies.
Ronald D. Cohn,Kevin P. Campbell +1 more
TL;DR: A large number of genes involved in muscular dystrophy encode components of the dystrophin‐glycoprotein complex (DGC) which normally links the intracellular cytoskeleton to the extracellular matrix, which is thought to lead to loss of sarcolemmal integrity and render muscle fibers more susceptible to damage.