T
Tobias Ragoczy
Researcher at Fred Hutchinson Cancer Research Center
Publications - 19
Citations - 8316
Tobias Ragoczy is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Locus control region & Chromatin. The author has an hindex of 11, co-authored 17 publications receiving 6938 citations. Previous affiliations of Tobias Ragoczy include University of Rochester & University of Washington.
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Journal ArticleDOI
Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
Erez Lieberman Aiden,Nynke L. van Berkum,Louise Williams,Maxim Imakaev,Tobias Ragoczy,Tobias Ragoczy,Agnes Telling,Agnes Telling,Ido Amit,Bryan R. Lajoie,Peter J. Sabo,Michael O. Dorschner,Richard Sandstrom,Bradley E. Bernstein,Bradley E. Bernstein,Michaël Bender,Mark Groudine,Mark Groudine,Andreas Gnirke,John A. Stamatoyannopoulos,Leonid A. Mirny,Eric S. Lander,Eric S. Lander,Job Dekker +23 more
TL;DR: Hi-C is described, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing and demonstrates the power of Hi-C to map the dynamic conformations of entire genomes.
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Developmental and species-divergent globin switching are driven by BCL11A
Vijay G. Sankaran,Jian Xu,Tobias Ragoczy,Gregory C. Ippolito,Carl R. Walkley,Carl R. Walkley,Shanna D. Maika,Yuko Fujiwara,Yuko Fujiwara,Masafumi Ito,Mark Groudine,Mark Groudine,Michaël Bender,Michaël Bender,Philip W. Tucker,Stuart H. Orkin,Stuart H. Orkin +16 more
TL;DR: It is shown that alterations in the expression of a trans-acting factor constitute a critical driver of gene expression changes during evolution, and BCL11A is a critical mediator of species-divergent globin switching.
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The locus control region is required for association of the murine β-globin locus with engaged transcription factories during erythroid maturation
TL;DR: The results suggest that the LCR-dependent association of the beta-globin locus with transcriptionally engaged Pol II foci provides the driving force for relocalization of the locus toward the nuclear interior during erythroid maturation.
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A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements
TL;DR: Evidence is shown that extrusion of a gene locus from a CT by itself is not necessarily indicative of transcriptional activity, but also can reflect a poised state for activation, as well as the previously documented transcriptionally active state.
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Multiple functions of Ldb1 required for β-globin activation during erythroid differentiation
TL;DR: It is shown that Ldb1 controls gene expression at multiple levels, and reduction of LDB1 results in the inability of the locus to migrate away from the nuclear periphery, which is necessary to achieve robust transcription of β-globin in nuclear transcription factories.