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Andreas Gnirke
Researcher at Massachusetts Institute of Technology
Publications - 16
Citations - 23473
Andreas Gnirke is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Genome & Nucleic acid. The author has an hindex of 9, co-authored 16 publications receiving 19031 citations. Previous affiliations of Andreas Gnirke include Harvard University & Baylor College of Medicine.
Papers
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Journal ArticleDOI
Full-length transcriptome assembly from RNA-Seq data without a reference genome.
Manfred Grabherr,Brian J. Haas,Moran Yassour,Moran Yassour,Joshua Z. Levin,Dawn Thompson,Ido Amit,Xian Adiconis,Lin Fan,Raktima Raychowdhury,Qiandong Zeng,Zehua Chen,Evan Mauceli,Nir Hacohen,Andreas Gnirke,Nicholas Rhind,Federica Di Palma,Bruce W. Birren,Chad Nusbaum,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Nir Friedman,Aviv Regev +22 more
TL;DR: The Trinity method for de novo assembly of full-length transcripts and evaluate it on samples from fission yeast, mouse and whitefly, whose reference genome is not yet available, providing a unified solution for transcriptome reconstruction in any sample.
Journal ArticleDOI
Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
Erez Lieberman Aiden,Nynke L. van Berkum,Louise Williams,Maxim Imakaev,Tobias Ragoczy,Tobias Ragoczy,Agnes Telling,Agnes Telling,Ido Amit,Bryan R. Lajoie,Peter J. Sabo,Michael O. Dorschner,Richard Sandstrom,Bradley E. Bernstein,Bradley E. Bernstein,Michaël Bender,Mark Groudine,Mark Groudine,Andreas Gnirke,John A. Stamatoyannopoulos,Leonid A. Mirny,Eric S. Lander,Eric S. Lander,Job Dekker +23 more
TL;DR: Hi-C is described, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing and demonstrates the power of Hi-C to map the dynamic conformations of entire genomes.
Journal ArticleDOI
Hi-C: a method to study the three-dimensional architecture of genomes.
Nynke L. van Berkum,Erez Lieberman-Aiden,Louise Williams,Maxim Imakaev,Andreas Gnirke,Leonid A. Mirny,Job Dekker,Eric S. Lander,Eric S. Lander +8 more
TL;DR: Hi-C, an extension of 3C that is capable of identifying long range interactions in an unbiased, genome-wide fashion, is developed, demonstrating that at the megabase scale Hi-C reveals features consistent with a fractal globule conformation.
Patent
Selection of nucleic acids by solution hybridization to oligonucleotide baits
TL;DR: In this paper, methods of selection of nucleic acids using solution hybridization, methods of sequencing nucleic acid including such selection methods, and products for use in the methods are disclosed.
Posted ContentDOI
A rapid, low cost, and highly sensitive SARS-CoV-2 diagnostic based on whole genome sequencing
Brian Glenn St Hilaire,Brian Glenn St Hilaire,Neva C. Durand,Neva C. Durand,Namita Mitra,Namita Mitra,Saul Godinez Pulido,Saul Godinez Pulido,Ragini Mahajan,Alyssa Blackburn,Alyssa Blackburn,Zane Colaric,Zane Colaric,Joshua W. M. Theisen,Joshua W. M. Theisen,David Weisz,David Weisz,Olga Dudchenko,Olga Dudchenko,Andreas Gnirke,Andreas Gnirke,Suhas S.P. Rao,Parwinder Kaur,Erez Lieberman Aiden,Aviva Presser Aiden +24 more
TL;DR: This work introduces a low-cost, high-throughput method for diagnosis of SARS-CoV-2 infection, dubbed Pathogen-Oriented Low-Cost Assembly & Re-Sequencing (POLAR), that enhances sensitivity by aiming to amplify the entire Sars-Cov-2 genome rather than targeting particular viral loci, as in typical RT-PCR assays.