M
Maxim Imakaev
Researcher at Massachusetts Institute of Technology
Publications - 74
Citations - 17464
Maxim Imakaev is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Chromatin & Chromosome conformation capture. The author has an hindex of 25, co-authored 66 publications receiving 13646 citations. Previous affiliations of Maxim Imakaev include Brigham and Women's Hospital.
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Journal ArticleDOI
Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
Erez Lieberman Aiden,Nynke L. van Berkum,Louise Williams,Maxim Imakaev,Tobias Ragoczy,Tobias Ragoczy,Agnes Telling,Agnes Telling,Ido Amit,Bryan R. Lajoie,Peter J. Sabo,Michael O. Dorschner,Richard Sandstrom,Bradley E. Bernstein,Bradley E. Bernstein,Michaël Bender,Mark Groudine,Mark Groudine,Andreas Gnirke,John A. Stamatoyannopoulos,Leonid A. Mirny,Eric S. Lander,Eric S. Lander,Job Dekker +23 more
TL;DR: Hi-C is described, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing and demonstrates the power of Hi-C to map the dynamic conformations of entire genomes.
Journal ArticleDOI
Formation of Chromosomal Domains by Loop Extrusion
Geoffrey Fudenberg,Maxim Imakaev,Carolyn Lu,Anton Goloborodko,Nezar Abdennur,Leonid A. Mirny,Leonid A. Mirny +6 more
TL;DR: This model produces TADs and finer-scale features of Hi-C data because each TAD emerges from multiple loops dynamically formed through extrusion, contrary to typical illustrations of single static loops.
Journal ArticleDOI
Iterative correction of Hi-C data reveals hallmarks of chromosome organization
Maxim Imakaev,Geoffrey Fudenberg,Rachel Patton McCord,Natalia Naumova,Anton Goloborodko,Bryan R. Lajoie,Job Dekker,Leonid A. Mirny,Leonid A. Mirny +8 more
TL;DR: In this article, the authors present a pipeline that integrates a strategy for mapping of sequencing reads and a data-driven method for iterative correction of biases, yielding genome-wide maps of relative contact probabilities.
Journal ArticleDOI
Organization of the Mitotic Chromosome
Natalia Naumova,Maxim Imakaev,Geoffrey Fudenberg,Geoffrey Fudenberg,Ye Zhan,Bryan R. Lajoie,Leonid A. Mirny,Job Dekker +7 more
TL;DR: Using polymer simulations, it is found that metaphase Hi-C data are inconsistent with classic hierarchical models and are instead best described by a linearly organized longitudinally compressed array of consecutive chromatin loops.
Organization of the Mitotic Chromosome
Natalia Naumova,Maxim Imakaev,Geoffrey Fudenberg,Geoffrey Fudenberg,Ye Zhan,Bryan R. Lajoie,Leonid A. Mirny,Job Dekker +7 more
TL;DR: In this article, the authors applied chromosome conformation capture methods, 5C and Hi-C, across the cell cycle and revealed two distinct three-dimensional folding states of the human genome.