T
Tom Huizinga
Researcher at Leiden University Medical Center
Publications - 14
Citations - 623
Tom Huizinga is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Rheumatoid arthritis & Arthritis. The author has an hindex of 6, co-authored 14 publications receiving 586 citations.
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Journal ArticleDOI
Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis
Diane van der Woude,Solbritt Rantapää-Dahlqvist,Andreea Ioan-Facsinay,Carla Onnekink,Carla M. Schwarte,Kirsten N Verpoort,Jan W. Drijfhout,Tom Huizinga,René E. M. Toes,Ger J. M. Pruijn +9 more
TL;DR: Epitope spreading with an increase in the recognition of citrullinated antigens occurs before the onset of RA, and immunological differences in ACPA fine specificity between UA–UA patients and UA–RA patients are associated with the future disease course.
Journal ArticleDOI
Protection against anti–citrullinated protein antibody–positive rheumatoid arthritis is predominantly associated with HLA–DRB1*1301: A meta-analysis of HLA–DRB1 associations with anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis in four European populations
Diane van der Woude,Benedicte A. Lie,Emeli Lundström,Alejandro Balsa,Anouk L. Feitsma,Jeanine J. Houwing-Duistermaat,Willem Verduijn,Gry B. N. Nordang,Lars Alfredsson,Lars Klareskog,Dora Pascual-Salcedo,Miguel A. González-Gay,Miguel A. López-Nevot,Fernando Valero,Bart O. Roep,Tom Huizinga,Tore K Kvien,Javier Martín,Leonid Padyukov,René R. P. de Vries,René E. M. Toes +20 more
TL;DR: The data do not support any of the classifications of protective alleles and indicate that protection against ACPA-positive RA is predominantly associated with HLA-DRB1*1301, with the strongest association in northern European countries.
Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: A meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations - Commentary
TL;DR: In this paper, the authors performed a meta-analysis of 4 European populations to investigate which HLA-DRB1 alleles are associated with protection in anti-citrullinated protein antibody (ACPA)-positive RA and ACPA-negative RA.
Journal ArticleDOI
Repair of joint erosions in rheumatoid arthritis: prevalence and patient characteristics in a large inception cohort
Michael P M van der Linden,Ramona Boja,N.B. Klarenbeek,Tom Huizinga,Désirée van der Heijde,Annette H M van der Helm-van Mil +5 more
TL;DR: Investigation of the frequency of repair and patients' characteristics associated with repair in an inception cohort of rheumatoid arthritis patients found repair occurred in 7.2% of the patients with RA, particularly in clinically inactive joints in patients with severe destructive disease.