P
Peter A. Nigrovic
Researcher at Boston Children's Hospital
Publications - 256
Citations - 13858
Peter A. Nigrovic is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Arthritis & Rheumatoid arthritis. The author has an hindex of 54, co-authored 230 publications receiving 10555 citations. Previous affiliations of Peter A. Nigrovic include VA Boston Healthcare System & Harvard University.
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Journal ArticleDOI
Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production
Eric Boilard,Peter A. Nigrovic,Peter A. Nigrovic,Katherine Larabee,Gerald F. Watts,Jonathan S. Coblyn,Michael E. Weinblatt,Elena Massarotti,Eileen Remold-O'Donnell,Richard W. Farndale,Jerry Ware,David M. Lee +11 more
TL;DR: A previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases is demonstrated and the collagen receptor glycoprotein VI is identified as a key trigger for platelet microparticle generation in arthritis pathophysiology.
Journal ArticleDOI
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Deepak A. Rao,Michael F. Gurish,Jennifer L. Marshall,Kamil Slowikowski,Chamith Y. Fonseka,Yanyan Liu,Laura T. Donlin,Lauren A. Henderson,Kevin Wei,Fumitaka Mizoguchi,Nikola Teslovich,Nikola Teslovich,Michael E. Weinblatt,Elena Massarotti,Jonathan S. Coblyn,Simon M. Helfgott,Yvonne C. Lee,Derrick J. Todd,Vivian P. Bykerk,Susan M. Goodman,Susan M. Goodman,Alessandra B. Pernis,Lionel B. Ivashkiv,Elizabeth W. Karlson,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,James A. Lederer,Soumya Raychaudhuri,Michael B. Brenner +30 more
TL;DR: Using multidimensional cytometry, transcriptomics, and functional assays, a population of PD-1hiCXCR5− ‘peripheral helper’ T (TPH) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF are defined.
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On the Alert for Cytokine Storm: Immunopathology in COVID-19.
Lauren A. Henderson,Scott W. Canna,Grant S. Schulert,Stefano Volpi,Pui Y. Lee,Kate F. Kernan,Roberto Caricchio,Shawn A. Mahmud,Melissa M. Hazen,Olha Halyabar,Kacie J Hoyt,Joseph Han,Alexei A. Grom,Marco Gattorno,Angelo Ravelli,Fabrizio De Benedetti,Edward M. Behrens,Randy Q. Cron,Peter A. Nigrovic +18 more
TL;DR: While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID‐19.
Journal ArticleDOI
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation
Luc H. Boudreau,Anne Claire Duchez,Nathalie Cloutier,Denis Soulet,Nicolas Martin,James G. Bollinger,Alexandre Paré,Matthieu Rousseau,Gajendra S. Naika,Tania Lévesque,Cynthia Laflamme,Geneviève Marcoux,Gérard Lambeau,Richard W. Farndale,Marc Pouliot,Hind Hamzeh-Cognasse,Fabrice Cognasse,Olivier Garraud,Peter A. Nigrovic,Helga Guderley,Steve Lacroix,Louis Thibault,John W. Semple,Michael H. Gelb,Eric Boilard +24 more
TL;DR: It is shown that activated platelets release respiratory-competent mitochondria, both within membrane-encapsulated microparticles and as free organelles, at the midpoint of a potent mechanism leading to inflammatory responses.
Journal ArticleDOI
Aggregatibacter actinomycetemcomitans–induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis
Maximilian F. Konig,Loreto Abusleme,Jesper Reinholdt,Robert J. Palmer,Ricardo Teles,Ricardo Teles,Kevon Sampson,Antony Rosen,Peter A. Nigrovic,Peter A. Nigrovic,Jeremy Sokolove,Jon T. Giles,Niki M. Moutsopoulos,Felipe Andrade +13 more
TL;DR: It is demonstrated that a particular periodontal pathogen called Aggregatibacter actinomycetemcomitans (Aa) induces changes in neutrophil function, including hypercitrullination of host proteins, an abnormality that is also observed in the joints of patients with rheumatoid arthritis.