T
Tomofumi Miyamoto
Researcher at Kyushu University
Publications - 278
Citations - 5182
Tomofumi Miyamoto is an academic researcher from Kyushu University. The author has contributed to research in topics: Triterpene & Ganglioside. The author has an hindex of 35, co-authored 271 publications receiving 4500 citations. Previous affiliations of Tomofumi Miyamoto include Wonkwang University & Mashhad University of Medical Sciences.
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Journal ArticleDOI
Identification of distinct ligands for the C-type lectin receptors mincle and dectin-2 in the pathogenic fungus Malassezia
Tetsuaki Ishikawa,Fumie Itoh,Sayumi Yoshida,Shinobu Saijo,Shinobu Saijo,Tetsuhiro Matsuzawa,Tohru Gonoi,Takashi Saito,Yoshio Okawa,Nobuyuki Shibata,Tomofumi Miyamoto,Sho Yamasaki +11 more
TL;DR: It is reported that Malassezia, an opportunistic skin fungal pathogen, is cooperatively recognized by Mincle and Dectin-2 through distinct ligands.
Journal ArticleDOI
Cytotoxic Lavandulyl Flavanones from Sophora flavescens
Tai Hyun Kang,Sei Joon Jeong,Won Gil Ko,Na-Young Kim,Byung-Hoon Lee,Masanori Inagaki,Tomofumi Miyamoto,Ryuichi Higuchi,Youn-Chul Kim +8 more
TL;DR: Two new lavandulylated flavanones were isolated from the root of Sophora flavescens and exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.
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Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity.
Masahiro Nagata,Yoshihiro Izumi,Eri Ishikawa,Ryoko Kiyotake,Rieko Doi,Satoru Iwai,Zakaria Omahdi,Toshiyuki Yamaji,Tomofumi Miyamoto,Takeshi Bamba,Sho Yamasaki +10 more
TL;DR: This study isolated endogenous glycolipids derived from damaged cells and identified a ubiquitous intracellular metabolite, β-glucosylceramide (GlcCer), as a Mincle ligand, suggesting that β-Glc cer is an endogenous ligand for Mincle and possesses immunostimulatory activity.
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Antifungal Steroid Saponins from Dioscorea cayenensis
Marc Sautour,Anne Claire Mitaine-Offer,Tomofumi Miyamoto,Alain Bertrand Dongmo,Marie-Aleth Lacaille-Dubois +4 more
TL;DR: Compound 2 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 12.5, 12. 5 and 25 micro g/mL, respectively) whereas 3 showed weak activity and 1 was inactive.
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Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses
Ryoko Kiyotake,Masatsugu Oh-hora,Eri Ishikawa,Tomofumi Miyamoto,Tatsuro Ishibashi,Sho Yamasaki,Sho Yamasaki +6 more
TL;DR: The results suggest that cholesterol crystals are an endogenous ligand for hMincle and that they activate innate immune responses.