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Shinobu Saijo
Researcher at Chiba University
Publications - 97
Citations - 10231
Shinobu Saijo is an academic researcher from Chiba University. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 44, co-authored 94 publications receiving 9094 citations. Previous affiliations of Shinobu Saijo include University of Tokyo & National Presto Industries.
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Journal ArticleDOI
Functional Specialization of Interleukin-17 Family Members
TL;DR: The identified functions of each IL-17 family member are described and the potential of these molecules as therapeutic targets are discussed.
Journal ArticleDOI
Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice
Reiko Horai,Shinobu Saijo,Hidetoshi Tanioka,Susumu Nakae,Katsuko Sudo,Akihiko Okahara,Toshimi Ikuse,Masahide Asano,Yoichiro Iwakura +8 more
TL;DR: It is shown that IL-1ra gene deficiency causes autoimmunity and joint-specific inflammation and suggested that IL -1ra is important in maintaining homeostasis of the immune system.
Journal ArticleDOI
Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans
Shinobu Saijo,Satoshi Ikeda,Keiko Yamabe,Shigeru Kakuta,Harumichi Ishigame,Aoi Akitsu,Noriyuki Fujikado,Toshimasa Kusaka,Sachiko Kubo,Soo Hyun Chung,Ryohei Komatsu,Noriko Miura,Yoshiyuki Adachi,Naohito Ohno,Kazutoshi Shibuya,Natsuo Yamamoto,Kazuyoshi Kawakami,Sho Yamasaki,Takashi Saito,Shizuo Akira,Yoichiro Iwakura +20 more
TL;DR: This study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation and generates Clec4n(-/-) mice that had virtually no fungal alpha-mannan-induced cytokine production.
Journal ArticleDOI
Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.
Shinobu Saijo,Noriyuki Fujikado,Takahisa Furuta,Soo Hyun Chung,Hayato Kotaki,Keisuke Seki,Katsuko Sudo,Shizuo Akira,Yoshiyuki Adachi,Naohito Ohno,Takeshi Kinjo,Kiwamu Nakamura,Kazuyoshi Kawakami,Yoichiro Iwakura +13 more
TL;DR: Protective immunity to pneumocystis, but not to candida, required dectin-1 for the production of antifungal reactive oxygen species, and wild-type and dectIn-1-knockout mice were equally susceptible to candidA infection.
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IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
TL;DR: Observations suggest that IL-17 plays a crucial role in T cell activation, downstream of IL-1, causing the development of autoimmune arthritis.