Identification of distinct ligands for the C-type lectin receptors mincle and dectin-2 in the pathogenic fungus Malassezia
Tetsuaki Ishikawa,Fumie Itoh,Sayumi Yoshida,Shinobu Saijo,Shinobu Saijo,Tetsuhiro Matsuzawa,Tohru Gonoi,Takashi Saito,Yoshio Okawa,Nobuyuki Shibata,Tomofumi Miyamoto,Sho Yamasaki +11 more
TLDR
It is reported that Malassezia, an opportunistic skin fungal pathogen, is cooperatively recognized by Mincle and Dectin-2 through distinct ligands.About:
This article is published in Cell Host & Microbe.The article was published on 2013-04-17 and is currently open access. It has received 181 citations till now. The article focuses on the topics: C-type lectin & Malassezia.read more
Citations
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The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL
Berk Aykut,Smruti Pushalkar,Ruonan Chen,Qianhao Li,Raquel Abengozar,Jacqueline I. Kim,Sorin A. A. Shadaloey,Dongling Wu,Pamela Preiss,Narendra Verma,Yuqi Guo,Anjana Saxena,Anjana Saxena,Mridula Vardhan,Brian Diskin,Wei Wang,Joshua Leinwand,Emma Kurz,Juan A. Kochen Rossi,Mautin Hundeyin,Constantinos Zambrinis,Xin Li,Deepak Saxena,George Miller +23 more
TL;DR: It is shown that fungi migrate from the gut lumen to the pancreas, and that this is implicated in the pathogenesis of pancreatic ductal adenocarcinoma (PDA), and that pathogenic fungi promote PDA by driving the complement cascade through the activation of MBL.
Journal ArticleDOI
C-type lectins in immunity: recent developments.
Ivy M. Dambuza,Gordon D. Brown +1 more
TL;DR: CLRs play an essential role in immunity to fungi and mycobacteria and are involved in the regulation of homeostasis, autoimmunity and allergy.
Journal ArticleDOI
Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models.
Jose J. Limon,Jie Tang,Dalin Li,Andrea J. Wolf,Kathrin S. Michelsen,Vince Funari,Matthew Gargus,Christopher Nguyen,Purnima Sharma,Viviana I. Maymi,Iliyan D. Iliev,Joseph H. Skalski,Joseph H. Skalski,Jordan Brown,Carol J. Landers,James Borneman,Jonathan Braun,Stephan R. Targan,Dermot P.B. McGovern,David M. Underhill,David M. Underhill +20 more
TL;DR: In this article, the authors characterized fungi directly associated with the intestinal mucosa in healthy people and Crohn's disease patients and identified fungi specifically abundant in patients, including Malassezia restricta, which elicits strong inflammatory cytokine production from innate cells harboring the IBD-linked polymorphism in CARD9.
Journal ArticleDOI
Fungal dysbiosis: immunity and interactions at mucosal barriers.
Iliyan D. Iliev,Irina Leonardi +1 more
TL;DR: It is proposed that gut microbiota dysbiosis is a collective feature of complex interactions between prokaryotic and eukaryotic microbial communities that can affect immunity and that can influence health and disease.
Journal ArticleDOI
Signalling C‐Type lectin receptors, microbial recognition and immunity
TL;DR: This review will focus on the recognition of bacterial, viral and parasitic pathogens by CLRs, and how these receptors influence the outcome of infection, and provides a brief update on the role of CLRs in antifungal immunity.
References
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Pattern Recognition Receptors and Inflammation
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed.
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A simple and rapid method for the permethylation of carbohydrates
Ionel Ciucanu,Francisc Kerek +1 more
TL;DR: In this paper, a new method for the permethylation of sugars involving methyl iodide, a solid base (NaOH, KOH, or tert-BuOH/NaOH), and methyl sulphoxide was suggested.
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Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2
TL;DR: It is shown that whole Gram-positive bacteria, sPGN and LTA induce the activation of NF-κB in HEK293 cells expressing TLR2 but not in cells expressingTLR1 or TLR4, which identifies TLR 2 as a signal transducer for sPGn and Lta in addition to LPS.
Journal ArticleDOI
C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells
Carol Anne Ogden,Aimee deCathelineau,Peter R. Hoffmann,Donna L. Bratton,Berhane Ghebrehiwet,Valerie A. Fadok,Peter M. Henson +6 more
TL;DR: Evidence is provided that C1q and mannose binding lectin (MBL), a member of the collectin family of proteins, bind to apoptotic cells and stimulate ingestion of these by ligation on the phagocyte surface of the multifunctional protein, calreticulin.
Journal ArticleDOI
Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans
Shinobu Saijo,Satoshi Ikeda,Keiko Yamabe,Shigeru Kakuta,Harumichi Ishigame,Aoi Akitsu,Noriyuki Fujikado,Toshimasa Kusaka,Sachiko Kubo,Soo Hyun Chung,Ryohei Komatsu,Noriko Miura,Yoshiyuki Adachi,Naohito Ohno,Kazutoshi Shibuya,Natsuo Yamamoto,Kazuyoshi Kawakami,Sho Yamasaki,Takashi Saito,Shizuo Akira,Yoichiro Iwakura +20 more
TL;DR: This study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation and generates Clec4n(-/-) mice that had virtually no fungal alpha-mannan-induced cytokine production.
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