T
Tomohide Yamazaki
Researcher at Juntendo University
Publications - 8
Citations - 2395
Tomohide Yamazaki is an academic researcher from Juntendo University. The author has contributed to research in topics: CD28 & T cell. The author has an hindex of 8, co-authored 8 publications receiving 2221 citations.
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Journal ArticleDOI
Expression of Programmed Death 1 Ligands by Murine T Cells and APC
Tomohide Yamazaki,Hisaya Akiba,Hideyuki Iwai,Hironori Matsuda,Mami Aoki,Yuka Tanno,Tahiro Shin,Haruo Tsuchiya,Drew M. Pardoll,Ko Okumura,Miyuki Azuma,Hideo Yagita +11 more
TL;DR: B7-H1 was broadly expressed on the surface of mouse tumor cell lines while the expression of B7-DC was rather restricted, and the inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms ofPD-1-mediated immune regulation.
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The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.
Mohammed Javeed I. Ansari,Alan D. Salama,Alan D. Salama,Tanuja Chitnis,Tanuja Chitnis,R. Neal Smith,Hideo Yagita,Hisaya Akiba,Tomohide Yamazaki,Miyuki Azuma,Hideyuki Iwai,Samia J. Khoury,Hugh Auchincloss,Mohamed H. Sayegh,Mohamed H. Sayegh +14 more
TL;DR: A central role for PD-1–PD-L1 interaction in the regulation of induction and progression of autoimmune diabetes in the NOD mouse is demonstrated and the rationale to develop new therapies to target this costimulatory pathway in this disease is provided.
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The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo
Hisaya Akiba,Kazuyoshi Takeda,Yuko Kojima,Yoshihiko Usui,Norihiro Harada,Tomohide Yamazaki,Juan Ma,Katsunari Tezuka,Hideo Yagita,Ko Okumura +9 more
TL;DR: Results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ TFH cells in vivo.
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Blockade of B7-H1 on Macrophages Suppresses CD4+ T Cell Proliferation by Augmenting IFN-γ-Induced Nitric Oxide Production
TL;DR: Results indicated that the inhibition of T cell proliferation by anti-B7-H1 mAb was due to enhanced IFN-γ production, which augmented NO production by macrophages, suggesting a critical role for B7- H1 on macrophage in regulating IFN -γ production by naive CD4+ T cells and, hence, NO productionBy macrophaged.
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Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses
Fumihiko Tsushima,Hideyuki Iwai,Noriko Otsuki,Masaaki Abe,Sachiko Hirose,Tomohide Yamazaki,Hisaya Akiba,Hideo Yagita,Yuzo Takahashi,Ken Omura,Ko Okumura,Miyuki Azuma +11 more
TL;DR: The results demonstrate the regulatory role of PD‐1 and the differential roles of B 7‐H1 and B7‐DC in hapten‐induced immune responses and suggest the PD‐ 1‐B7‐H 1 pathway may play a unique role in regulating inflammatory responses.