Tomoko Sonoda

TL;DR: The results confirm the frequent methylation and silencing of Wnt antagonist genes in breast cancer, and suggest that their loss of function contributes to activated Wnt signalling in breast carcinogenesis.

TL;DR: It is demonstrated that Dickkopfs (Dkks) are frequent targets of epigenetic silencing in gastrointestinal tumors, and that loss of DKKs may facilitate tumorigenesis through beta-catenin/T-cell factor-independent mechanisms.

TL;DR: In this paper, the authors performed a case-control study on dietary factors and prostate cancer in order to assess the hypothesis that the traditional Japanese diet reduces the risk of prostate cancer and found that consumption of fish, all soybean products, tofu (bean curds), and natto (fermented soybeans) was associated with decreased risk.

TL;DR: Data suggest that the silencing of DFNA5 occurs frequently in gastric cancer and may play a key role in development and progression of the disease.

TL;DR: A wide variation in the impact of dietary factors by sex and cancer site is indicated, pointing to a necessity for careful interpretation in the contribution of individual dietary factors to development of human cancers in Hokkaido, Japan.