R
Reo Maruyama
Researcher at Japanese Foundation for Cancer Research
Publications - 108
Citations - 8072
Reo Maruyama is an academic researcher from Japanese Foundation for Cancer Research. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 44, co-authored 96 publications receiving 7084 citations. Previous affiliations of Reo Maruyama include Ben-Gurion University of the Negev & Brigham and Women's Hospital.
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Journal ArticleDOI
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
Lauren L. C. Marotta,Vanessa Almendro,Vanessa Almendro,Andriy Marusyk,Michail Shipitsin,Janina Schemme,Sarah R. Walker,Noga Bloushtain-Qimron,Jessica J. Kim,Sibgat Choudhury,Reo Maruyama,Zhenhua Wu,Mithat Gonen,Laura Mulvey,Marina Bessarabova,Sung Jin Huh,Serena J. Silver,So Young Kim,So Young Kim,So Yeon Park,Hee Eun Lee,Karen S. Anderson,Andrea L. Richardson,Tatiana Nikolskaya,Yuri Nikolsky,X. Shirley Liu,David E. Root,William C. Hahn,William C. Hahn,David A. Frank,Kornelia Polyak +30 more
TL;DR: The IL-6/JAK2/Stat3 pathway was preferentially active in CD44+CD24- breast cancer cells compared with other tumor cell types, and inhibition of JAK2 decreased their number and blocked growth of xenografts.
Journal ArticleDOI
Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.
Minoru Toyota,Hiromu Suzuki,Yasushi Sasaki,Reo Maruyama,Kohzoh Imai,Yasuhisa Shinomura,Takashi Tokino +6 more
TL;DR: The results suggest that miR-34b/c and BTG4 are novel tumor suppressors in CRC and that the miR/c CpG island, which bidirectionally regulates miR’s 34b-34c and 4B-cell translocation gene 4, is a frequent target of epigenetic silencing in CRC.
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Fusobacterium in colonic flora and molecular features of colorectal carcinoma
Tomomitsu Tahara,Tomomitsu Tahara,Eiichiro Yamamoto,Hiromu Suzuki,Reo Maruyama,Woonbok Chung,Judith Garriga,Jaroslav Jelinek,Hiro O. Yamano,Tamotsu Sugai,Byonggu An,Imad Shureiqi,Minoru Toyota,Yutaka Kondo,Marcos R. Estecio,Jean Pierre J. Issa +15 more
TL;DR: It is shown that Fusobacterium enrichment is associated with specific molecular subsets of colorectal cancers, offering support for a pathogenic role in coloreCTal cancer for this gut microbiome component.
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Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors
Takeshi Niinuma,Hiromu Suzuki,Masanori Nojima,Katsuhiko Nosho,Hiroyuki Yamamoto,Hiroyuki Takamaru,Eiichiro Yamamoto,Reo Maruyama,Takayuki Nobuoka,Yasuaki Miyazaki,Toshirou Nishida,Takeo Bamba,Tatsuo Kanda,Yoichi Ajioka,Takahiro Taguchi,Satoshi Okahara,Hiroaki Takahashi,Yasunori Nishida,Masao Hosokawa,Tadashi Hasegawa,Takashi Tokino,Koichi Hirata,Kohzoh Imai,Minoru Toyota,Yasuhisa Shinomura +24 more
TL;DR: Findings reveal concurrent overexpression of HOX genes with noncoding RNAs in human cancer in this setting, revealing miR-196a and HOTAIR as potentially useful biomarkers and therapeutic targets in malignant GISTs.
Journal ArticleDOI
Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis
Kei Mitsuhashi,Katsuhiko Nosho,Yasutaka Sukawa,Yasutaka Matsunaga,Miki Ito,Hiroyoshi Kurihara,Shinichi Kanno,Hisayoshi Igarashi,Takafumi Naito,Yasushi Adachi,Mami Tachibana,Tokuma Tanuma,Hiroyuki Maguchi,Toshiya Shinohara,Tadashi Hasegawa,Masafumi Imamura,Yasutoshi Kimura,Koichi Hirata,Reo Maruyama,Hiromu Suzuki,Kohzoh Imai,Hiroyuki Yamamoto,Yasuhisa Shinomura +22 more
TL;DR: Tumor Fusobacterium species status is independently associated with a worse prognosis of pancreatic cancer, suggesting that FusOBacterium Species may be a prognostic biomarker of pancreatIC cancer.