T
Tomonao Inobe
Researcher at University of Toyama
Publications - 34
Citations - 1170
Tomonao Inobe is an academic researcher from University of Toyama. The author has contributed to research in topics: Proteasome & GroEL. The author has an hindex of 18, co-authored 34 publications receiving 1058 citations. Previous affiliations of Tomonao Inobe include University of Tokyo & Northwestern University.
Papers
More filters
Journal ArticleDOI
Defining the geometry of the two-component proteasome degron
TL;DR: It is found that a substrate is degraded efficiently only when its initiation region is of a certain minimal length and is appropriately separated in space from the proteasome-binding tag.
Journal ArticleDOI
Substrate selection by the proteasome during degradation of protein complexes
TL;DR: The degradation of model proteins is tested to reveal the molecular basis of subunit specificity in the degradation of protein complexes and provide a plausible explanation for how adaptor proteins can bind to otherwise stable proteins and target them for degradation.
Journal ArticleDOI
Sequence composition of disordered regions fine-tunes protein half-life
Susan Fishbain,Tomonao Inobe,Eitan Israeli,Sreenivas Chavali,Houqing Yu,Grace Kago,M. Madan Babu,Andreas T Matouschek +7 more
TL;DR: It is proposed that the proteasome's sequence preferences provide a second component to the degradation code and may fine-tune protein half-life in cells.
Journal ArticleDOI
Paradigms of protein degradation by the proteasome.
TL;DR: New structures of the proteasome particle show how its subunits are arranged and provide insights into how the prote asome is regulated.
Journal ArticleDOI
Fast Compaction of α-Lactalbumin During Folding Studied by Stopped-flow X-ray Scattering
Munehito Arai,Kazuki Ito,Tomonao Inobe,Masaharu Nakao,Kosuke Maki,Kiyoto Kamagata,Hiroshi Kihara,Yoshiyuki Amemiya,Kunihiro Kuwajima +8 more
TL;DR: In this article, the authors used a small-angle X-ray scattering technique combined with a two-dimensional charge-coupled device-based detector to monitor the fast compaction process during protein folding, and measured the kinetic refolding reaction of α-lactalbumin.