T
Tomoyo Hashimoto
Researcher at University of Occupational and Environmental Health Japan
Publications - 28
Citations - 563
Tomoyo Hashimoto is an academic researcher from University of Occupational and Environmental Health Japan. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Neuron. The author has an hindex of 10, co-authored 28 publications receiving 509 citations. Previous affiliations of Tomoyo Hashimoto include Tokyo Gas & Shinshu University.
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TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.
Masato Hasegawa,Tetsuaki Arai,Haruhiko Akiyama,Takashi Nonaka,Hiroshi Mori,Tomoyo Hashimoto,Mineo Yamazaki,Kiyomitsu Oyanagi +7 more
TL;DR: Accumulation of TDP-43 is a common process in certain neurodegenerative disorders, including FTLD-U, ALS and G-PDC, according to immunohistochemical and biochemical analyses of brains of Guamanians with the parkinsonism-dementia complex.
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Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in dopaminergic neurons.
TL;DR: The results indicated that Mg might protect dopaminergic neurons in the substantia nigra from degeneration and also ameliorate neurite pathology in a PD model, the first report to document a significant and striking effect of Mg for prevention of neurite and neuron pathology.
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Motor hand representation in cortical area 44
TL;DR: It is shown that single TMS of area 44 produces motor evoked potential from hand muscles, which is involved in voluntary hand movements and has direct fast-conducting corticospinal projections.
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Familial ALS with FUS P525L mutation: two Japanese sisters with multiple systems involvement
Yoko Mochizuki,Eiji Isozaki,Masaki Takao,Tomoyo Hashimoto,Makoto Shibuya,Makoto Arai,Masato Hosokawa,Akihito Kawata,Kiyomitsu Oyanagi,Ban Mihara,Toshio Mizutani +10 more
TL;DR: The clinicopathological features of familial amyotrophic lateral sclerosis with the fused in sarcoma (FUS) P525L mutation indicated a very active degeneration of motor neurons and multiple system degeneration, which led to marked brain and spinal cord atrophy in the long term clinical outcome.
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Amantadine-induced cortical myoclonus.
TL;DR: Three patients with amantadine-induced cortical myoclonus are described, including an 87-year-old woman with chronic renal failure on hemodialysis who developed generalized myoclonic jerking at the end of April 1999 and was admitted to the authors' department on May 27.