H
Hiroshi Mori
Researcher at Osaka City University
Publications - 247
Citations - 14204
Hiroshi Mori is an academic researcher from Osaka City University. The author has contributed to research in topics: Amyloid precursor protein & Alzheimer's disease. The author has an hindex of 58, co-authored 212 publications receiving 12903 citations. Previous affiliations of Hiroshi Mori include Gifu Pharmaceutical University & Kobe University.
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Journal ArticleDOI
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Tetsuaki Arai,Masato Hasegawa,Haruhiko Akiyama,Kenji Ikeda,Takashi Nonaka,Hiroshi Mori,David M. A. Mann,Kuniaki Tsuchiya,Mari Yoshida,Yoshio Hashizume,Tatsuro Oda +10 more
TL;DR: The common occurrence of intracellular accumulations of TDP-43 supports the hypothesis that these disorders represent a clinicopathological entity of a single disease, and suggests that they can be newly classified as a proteinopathy of T DP-43.
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Ubiquitin is a component of paired helical filaments in Alzheimer's disease
TL;DR: To obtain direct evidence that ubiquitin is a component of PHF, PHF were treated with concentrated formic acid and digested with lysylendopeptidase; ubiquitIn-derived peptides were then identified by reversed-phase high-performance liquid chromatography.
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Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
Takayuki Kondo,Masashi Asai,Masashi Asai,Kayoko Tsukita,Yumiko Kutoku,Yutaka Ohsawa,Yoshihide Sunada,Keiko Imamura,Naohiro Egawa,Naoki Yahata,Keisuke Okita,Kazutoshi Takahashi,Isao Asaka,Takashi Aoi,Akira Watanabe,Kaori Watanabe,Chie Kadoya,Rie Nakano,Dai Watanabe,Kei Maruyama,Osamu Hori,Satoshi Hibino,Tominari Choshi,Tatsutoshi Nakahata,Hiroyuki Hioki,Takeshi Kaneko,Motoko Naitoh,Katsuhiro Yoshikawa,Satoko Yamawaki,Shigehiko Suzuki,Ryuji Hata,Shu-ichi Ueno,Tsuneyoshi Seki,Kazuhiro Kobayashi,Tatsushi Toda,Kazuma Murakami,Kazuhiro Irie,William L. Klein,Hiroshi Mori,Takashi Asada,Ryosuke Takahashi,Nobuhisa Iwata,Shinya Yamanaka,Haruhisa Inoue +43 more
TL;DR: Differential manifestation of ER stress and DHA responsiveness may help explain variable clinical results obtained with the use of DHA treatment and suggests that DHA may in fact be effective for a subset of patients.
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A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia
Takami Tomiyama,Tetsu Nagata,Hiroyuki Shimada,Rie Teraoka,Akiko Fukushima,Hyoue Kanemitsu,Hiroshi Takuma,Ryozo Kuwano,Masaki Imagawa,Suzuka Ataka,Yasuhiro Wada,Eito Yoshioka,Tomoyuki Nishizaki,Yasuyoshi Watanabe,Hiroshi Mori +14 more
TL;DR: A novel amyloid precursor protein (APP) mutation is reported that may provide evidence to address the question of how soluble oligomers of Aβ are proposed to initiate synaptic and cognitive dysfunction in Alzheimer's disease.
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A Mouse Model of Amyloid β Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo
Takami Tomiyama,Shogo Matsuyama,Hiroyuki Iso,Tomohiro Umeda,Tomohiro Umeda,Hiroshi Takuma,Kiyouhisa Ohnishi,Kenichi Ishibashi,Rie Teraoka,Naomi Sakama,Takenari Yamashita,Kazuchika Nishitsuji,Kazuhiro Ito,Hiroyuki Shimada,Mary P. Lambert,William L. Klein,Hiroshi Mori,Hiroshi Mori +17 more
TL;DR: It is suggested that APP transgenic mice are a useful model of A β oligomer-induced pathology in the absence of amyloid plaques and that Aβ oligomers cause not only synaptic alteration but also other features of AD pathology.