M
Masato Hosokawa
Researcher at Institute of Medical Science
Publications - 60
Citations - 2553
Masato Hosokawa is an academic researcher from Institute of Medical Science. The author has contributed to research in topics: Frontotemporal lobar degeneration & Granulin. The author has an hindex of 23, co-authored 55 publications receiving 2143 citations. Previous affiliations of Masato Hosokawa include University of British Columbia & Nagoya City University.
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Journal ArticleDOI
Prion-like spreading of pathological α-synuclein in brain
Masami Masuda-Suzukake,Takashi Nonaka,Masato Hosokawa,Takayuki Oikawa,Tetsuaki Arai,Haruhiko Akiyama,David M. A. Mann,Masato Hasegawa +7 more
TL;DR: It is shown that intracerebral injections of sarkosyl-insoluble α- Synuclein from brains of patients with dementia with Lewy bodies induced hyperphosphorylated α-synuclein pathology in wild-type mice and injection of fibrils of recombinant human and mouse α- synuclein efficiently induced similar α-Synuclein pathologies inWild- type mice.
Journal ArticleDOI
Pathological alpha-synuclein propagates through neural networks
Masami Masuda-Suzukake,Takashi Nonaka,Masato Hosokawa,Maki Kubo,Aki Shimozawa,Haruhiko Akiyama,Masato Hasegawa +6 more
TL;DR: The data indicate that α-synuclein aggregation spread by prion-like mechanisms through neural networks in mouse brains and seems that accumulation of α- synuclein has a synergistic effect on tau and TDP-43 aggregation.
Journal ArticleDOI
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.
Keiko Imamura,Yuishin Izumi,Akira Watanabe,Kayoko Tsukita,Knut Woltjen,Takuya Yamamoto,Akitsu Hotta,Akitsu Hotta,Takayuki Kondo,Shiho Kitaoka,Akira Ohta,Akito Tanaka,Dai Watanabe,Mitsuya Morita,Hiroshi Takuma,Akira Tamaoka,Tilo Kunath,Selina Wray,Hirokazu Furuya,Takumi Era,Kouki Makioka,Koichi Okamoto,Takao Fujisawa,Hideki Nishitoh,Kengo Homma,Hidenori Ichijo,Jean-Pierre Julien,Nanako Obata,Masato Hosokawa,Haruhiko Akiyama,Satoshi Kaneko,Takashi Ayaki,Hidefumi Ito,Ryuji Kaji,Ryosuke Takahashi,Shinya Yamanaka,Haruhisa Inoue +36 more
TL;DR: Analysis of ALS patient iPSC-derived motor neurons indicates that Src/c-Abl inhibitors may have potential for treating ALS, and a phenotypic screen to repurpose existing drugs using ALS motor neuron survival as readout shows that inhibitors of Src or c-ABL kinases promoted autophagy and rescued ALS motor neurons from degeneration.
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Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease.
TL;DR: The weak inflammatory response and absence of NFTs indicate that tg mice are only a limited model of AD, which means that therapeutic strategies for the treatment of AD based on tg mouse models that overexpress Abeta may be limited in their application.
Journal ArticleDOI
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Yoshinori Tanaka,Genjiro Suzuki,Takashi Matsuwaki,Masato Hosokawa,Geidy E. Serrano,Thomas G. Beach,Keitaro Yamanouchi,Masato Hasegawa,Masugi Nishihara +8 more
TL;DR: It is shown PGRN is a secretory lysosomal protein that regulates lysOSomal function and biogenesis by controlling the acidification of lYSosomes and the change of P GRN levels led to a cell‐type‐specific increase of insoluble TDP‐43.