T
Toni K. Choueiri
Researcher at Harvard University
Publications - 1230
Citations - 84800
Toni K. Choueiri is an academic researcher from Harvard University. The author has contributed to research in topics: Renal cell carcinoma & Sunitinib. The author has an hindex of 107, co-authored 1071 publications receiving 59514 citations. Previous affiliations of Toni K. Choueiri include University of Ulsan & University of British Columbia.
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Journal ArticleDOI
Correlation of progression-free survival at 6 months (PFS6) with overall survival at 12 months (OS12) in an analysis of 10 trials of second-line therapy for advanced urothelial carcinoma (UC).
Benjamin L. Maughan,Kenneth M. Boucher,Neeraj Agarwal,Toni K. Choueiri,Angela Q. Qu,Nicholas J. Vogelzang,Ronan Fougeray,Guenter Niegisch,Peter Albers,Yu-Ning Wong,Yoo-Joung Ko,Srikala S. Sridhar,Matthew D. Galsky,Daniel P. Petrylak,Ulka N. Vaishampayan,Tomasz M. Beer,Cora N. Sternberg,Jonathan E. Rosenberg,Joaquim Bellmunt Molins,Guru Sonpavde +19 more
TL;DR: Second-line therapy of advanced UC is a significant unmet need and phase II trials have relied on response rate (RR) as a primary endpoint, but response may not be suitable for asse...
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A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer
Shuang G. Zhao,Jamie M. Sperger,Jennifer L. Schehr,Rana R. McKay,Hamid Emamekhoo,Anupama Singh,Zachery D. Schultz,Rory M. Bade,Charlotte N. Stahlfeld,Cole Gilsdorf,Camila Hernández,Serena K. Wolfe,Richel D Mayberry,Hannah Krause,Matthew L. Bootsma,Kyle T Helzer,Nicholas R. Rydzewski,Hamza Bakhtiar,Yue Shi,Grace C. Blitzer,Christos Kyriakopoulos,David Kosoff,Xiaopeng Wei,John M. Floberg,Nan Sethakorn,Marina N. Sharifi,Paul M. Harari,Wei Huang,Himisha Beltran,Toni K. Choueiri,Howard I. Scher,Dana E. Rathkopf,Susan Halabi,Andrew J. Armstrong,David J. Beebe,Menggang Yu,Kaitlin Sundling,Mary-Ellen Taplin,Joshua M. Lang +38 more
TL;DR: In this paper , the authors performed analytical validation of a Circulating Tumor Cell (CTC) multiplex RNA qPCR assay to identify the limit of quantification (LOQ) in cell lines, synthetic cDNA, and patient samples.
Journal ArticleDOI
Identification of a novel urothelial carcinoma (UC) biomarker of lethality.
Jonathan E. Rosenberg,Lillian Werner,Shamini Selvarajah,Barbara A. Weir,Meredith M. Regan,Susanna Jacobus,David M. Berman,Fabio A.B. Schutz,Robert O'Brien,Toni K. Choueiri,Jordi Barretina,Sabina Signoretti,Massimo Loda,Elizabeth A. Guancial,Enrique Gallardo,Federico Rojo,Josep Lloreta,William C. Hahn,Philip W. Kantoff,Joaquim Bellmunt +19 more
TL;DR: Genomic gain of a short segment of chromosome 1q23.3 is associated with a lethal phenotype of UC in patients with metastatic disease in a cohort of 94 UC patients uniformly-treated for distant metastases.
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ECOG score analysis as a proxy for health-related quality of life assessment in patients with poor or intermediate risk metastatic renal cell carcinoma from the CABOSUN trial (Alliance A031203).
Darren R. Feldman,Marion Feuilly,Jie Meng,Johanna Lister,Florence Marteau,Michael J. Morris,Daniel J. George,Toni K. Choueiri +7 more
TL;DR: CABOSUN, a randomized and open-label phase II trial, demonstrated significant improvement in progression-free survival (PFS) with cabozantinib versus sunitinib in the first-line treatment of multiple sclerosis.
Journal ArticleDOI
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma
Amin Nassar,Sarah Abou Alaiwi,Sylvan C. Baca,Elio Adib,Rosario I. Corona,Ji-Heui Seo,Marcos A. S. Fonseca,Sándor Spisák,Talal El Zarif,Viktoria Tisza,David A. Braun,Heng Du,Monica He,Abdallah Flaifel,Michel Alchoueiry,Thomas Denize,Sayed G Matar,Andres M. Acosta,Sachet A. Shukla,Yue Hou,John A. Steinharter,Gabrielle Bouchard,Jacob E. Berchuck,Edward P. O’Connor,Connor Bell,Pier Vitale Nuzzo,Gwo-Shu Mary Lee,Sabina Signoretti,Michelle S. Hirsch,Mark Pomerantz,Elizabeth P. Henske,Alexander Gusev,Kate Lawrenson,Toni K. Choueiri,David J. Kwiatkowski,Matthew L. Freedman +35 more
TL;DR: In this paper , the epigenome of renal cell carcinoma (RCC) was characterized by using ChIP-seq, ATAC-Seq, RNA-seq and SNP arrays.