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Tonyia Eaves-Pyles

Researcher at University of Texas Medical Branch

Publications -  37
Citations -  2094

Tonyia Eaves-Pyles is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Proinflammatory cytokine & Francisella tularensis. The author has an hindex of 21, co-authored 37 publications receiving 1866 citations. Previous affiliations of Tonyia Eaves-Pyles include Shriners Hospitals for Children - Galveston & University of Cincinnati Academic Health Center.

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Journal ArticleDOI

Flagellin, a Novel Mediator of Salmonella-Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction

Tonyia Eaves-Pyles, +7 more
- 15 Jan 2001 - 
TL;DR: It is proposed that flagellin released by Gram-negative pathogens may contribute to the inflammatory response by an LPS- and Toll-like receptor-4-independent pathway.
Journal ArticleDOI

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

Ye Zhao, +15 more
- 07 Feb 2018 - 
TL;DR: The studies demonstrated that microbiota metabolites SCFA promoted IEC RegIIIγ and β-defensins in a GPR43-dependent manner, providing a novel pathway by which microbiota regulates IEC expression of AMP and intestinal homeostasis.
Journal ArticleDOI

Salmonella Flagellin-Dependent Proinflammatory Responses Are Localized to the Conserved Amino and Carboxyl Regions of the Protein

Tonyia Eaves-Pyles, +4 more
- 15 Dec 2001 - 
TL;DR: The potent proinflammatory activity of flagellin resides in the highly conserved N and C D1 and D2 regions of the Salmonella dublin gene.
Journal ArticleDOI

Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells

Tonyia Eaves-Pyles, +7 more
- 01 Jul 2008 - 
TL;DR: Findings demonstrate that E. coli O83:H1 possesses the characteristics of the AIEC LF82 strain that may contribute to the low-grade, chronic inflammation observed in Crohn's disease.
Journal ArticleDOI

Critical role for serum opsonins and complement receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella tularensis by human dendritic cells (DC): uptake of Francisella leads to activation of immature DC and intracellular survival of the bacteria

Abdelhakim Ben Nasr, +5 more
- 01 Oct 2006 - 
TL;DR: It is shown that optimal phagocytosis of LVS by DC is dependent on serum opsonization, and it is demonstrated that complement factor C3‐derived opsonins and the major complement receptors expressed by DC, the integrins CR3 and CR4, play a critical role in this adhesion‐mediated phagcytosis.