Toru Itakura

TL;DR: To visualize and isolate live dopamine (DA)-producing neurons in the embryonic ventral mesencephalon and isolate an enriched population of DA neurons from brain tissue, transgenic mice expressing green fluorescent protein (GFP) are generated under the control of the rat tyrosine hydroxylase gene promoter.

TL;DR: These findings indicate that precursor cells harvested from the embryonic ventral mesencephalon can generate dopaminergic neurons able to restore function to the chemically denervated adult striatum.

TL;DR: The results clearly indicate that HAE cells capable of producing DA can survive and function in the brain of a rat model of PD and further studies are needed to develop strategies to enhance the ability of Hae cells to produce DA as well as the graft survival.

TL;DR: Although the factors that contribute to the currently observed effects remain to be fully determined, implantation of HAE cells could be a viable strategy to counteract the loss of DA neurons in Parkinson's disease.

TL;DR: The results indicate that EphA4 plays an important role in malignant phenotypes of glioblastoma by enhancing cell proliferation and migration through accelerating a canonical FGFR signaling pathway.