Toru Moriguchi

TL;DR: The results suggest that learning and cognitive behavior are related to brain DHA status, which, in turn, is related to the levels of themilk/dietary n‐3 fatty acids.

TL;DR: It is shown that mice deficient in the M3 muscarinic receptor (M3R-/- mice) display a significant decrease in food intake, reduced body weight and peripheral fat deposits, and very low levels of serum leptin and insulin, and there may be a cholinergic pathway that involves M3-receptor-mediated facilitation of food intake at a site downstream of the hypothalamic leptin/melanocortin system and upstream of the MCH system.

TL;DR: The results indicate that animals repleted since birth or at weaning were able to achieve nearly the same level of brain DHA and spatial task performance as animals maintained for three generations on an n‐3 adequate diet.

TL;DR: It is indicated that rats with decreased DHA levels in the central nervous system perform poorer in these tasks compared to rats with higher DHA Levels and suggest the presence of learning deficits in these animals.

TL;DR: A consideration of the total amounts and time courses of DHA repleted in the nervous system compared with the liver and circulation suggests that transport-related processes may limit the rate of D HA repletion in the retina and brain.