A
Akihiro Yamanaka
Researcher at Nagoya University
Publications - 192
Citations - 10770
Akihiro Yamanaka is an academic researcher from Nagoya University. The author has contributed to research in topics: Orexin & Wakefulness. The author has an hindex of 47, co-authored 169 publications receiving 8965 citations. Previous affiliations of Akihiro Yamanaka include Canon Inc. & National Presto Industries.
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Journal ArticleDOI
Hypothalamic orexin neurons regulate arousal according to energy balance in mice.
Akihiro Yamanaka,Carsten T. Beuckmann,Jon T. Willie,Junko Hara,Natsuko Tsujino,Michihiro Mieda,Makoto Tominaga,Ken-ichi Yagami,Fumihiro Sugiyama,Katsutoshi Goto,Masashi Yanagisawa,Masashi Yanagisawa,Takeshi Sakurai +12 more
TL;DR: It is demonstrated that hypothalamic orexin neurons monitor indicators of energy balance and mediate adaptive augmentation of arousal in response to fasting, indicating that orexIn neurons provide a crucial link between energy Balance and arousal.
Journal ArticleDOI
Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice.
Takeshi Sakurai,Ruby Nagata,Akihiro Yamanaka,Hiroko Kawamura,Natsuko Tsujino,Yo Muraki,Haruaki Kageyama,Satoshi Kunita,Satoru Takahashi,Katsutoshi Goto,Yoshimasa Koyama,Seiji Shioda,Masashi Yanagisawa +12 more
TL;DR: It is revealed that orexin neurons receive input from several brain areas, including the amygdala, basal forebrain cholinergic neurons, GABAergic neuron in the preoptic area, and serotonergic neurons in the median/paramedian raphe nuclei.
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Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response
Raphaelle Winsky-Sommerer,Akihiro Yamanaka,Sabrina Diano,Erzsebet Borok,Amanda J. Roberts,Takeshi Sakurai,Thomas S. Kilduff,Tamas L. Horvath,Luis de Lecea +8 more
TL;DR: It is proposed that, after stressor stimuli, CRF stimulates the release of hypocretins and that this circuit contributes to activation and maintenance of arousal associated with the stress response.
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Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.
Koji Toshinai,Hideki Yamaguchi,Yuxiang Sun,Roy G. Smith,Akihiro Yamanaka,Takeshi Sakurai,Yukari Date,Muhtashan S. Mondal,Takuya Shimbara,Takashi Kawagoe,Noboru Murakami,Mikiya Miyazato,Kenji Kangawa,Masamitsu Nakazato +13 more
TL;DR: Central des-acyl ghrelin may activate orexin-expressing neurons, perhaps functioning in feeding regulation through interactions with a target protein distinct from the GHS-R.
Journal ArticleDOI
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
Masahisa Yamada,Tsuyoshi Miyakawa,Tsuyoshi Miyakawa,Alokesh Duttaroy,Akihiro Yamanaka,Toru Moriguchi,Ryosuke Makita,Masaharu Ogawa,Chieh J. Chou,Bing Xia,Jacqueline N. Crawley,Christian C. Felder,Chu-Xia Deng,Jürgen Wess +13 more
TL;DR: It is shown that mice deficient in the M3 muscarinic receptor (M3R-/- mice) display a significant decrease in food intake, reduced body weight and peripheral fat deposits, and very low levels of serum leptin and insulin, and there may be a cholinergic pathway that involves M3-receptor-mediated facilitation of food intake at a site downstream of the hypothalamic leptin/melanocortin system and upstream of the MCH system.