T
Toshiaki Ohteki
Researcher at Tokyo Medical and Dental University
Publications - 101
Citations - 11925
Toshiaki Ohteki is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 44, co-authored 99 publications receiving 11150 citations. Previous affiliations of Toshiaki Ohteki include Keio University & Ontario Institute for Cancer Research.
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Journal ArticleDOI
Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo
Toshiaki Ohteki,Hiroyuki Tada,Kazuto Ishida,Taku Sato,Chikako Maki,Taketo Yamada,Junji Hamuro,Shigeo Koyasu +7 more
TL;DR: The importance of DC-derived IL-15 as a mediator of inflammatory responses in vivo is indicated, as demonstrated by granuloma formation and lethal endotoxin shock observed in established models of Propionibacterium acnes and zymosan-induced liver inflammation.
Journal ArticleDOI
Stringent V beta requirement for the development of NK1.1+ T cell receptor-alpha/beta+ cells in mouse liver.
Toshiaki Ohteki,H R MacDonald +1 more
TL;DR: In this article, the authors show that congenic C57BL/6.1 transgenic mice, which lack Vbeta8- expressing T cells owing to a genomic deletion at the Vbeta locus, maintain normal levels of liver NK1+T cells.
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Identification of activated T cell receptor gamma delta lymphocytes in the liver of tumor-bearing hosts.
Shuhji Seki,Toru Abo,Takayuki Masuda,Toshiaki Ohteki,A Kanno,Kazuyoshi Takeda,Hidemi Rikiishi,H Nagura,K Kumagai +8 more
TL;DR: It is demonstrated that a large proportion of TcR gamma delta cells were detectable in the liver, but not other lymphoid organs of cancer patients, and the majority of such cells were shown to be lymphoblastic by electron microscopy.
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Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness
Toshiaki Ohteki,H R MacDonald +1 more
TL;DR: The results suggest that CD28− IEL may follow a different developmental pathway from that of CD28+ IEL in a thymus‐independent environment, and that expression ofCD28 correlates with responsiveness of the cells to triggering via the TcR‐CD3 complex.
Stringent V~3 Requirement for the Development of NKI.1 + T Cell Receptor--cx/~ + Cells in Mouse Liver
TL;DR: The liver of C57BL/6 mice contains a major subset of CD4+8- and CD4-8- T cell receptor (TCR)-alpha/beta+ cells expressing the polymorphic natural killer NK1.1 surface marker, which indicates that liver NK1+T cells have a stringent requirement for expression of TCR-Vbeta8.2, Vbeta7, or Vbeta2 for their development.