T
Toshiaki Ohteki
Researcher at Tokyo Medical and Dental University
Publications - 101
Citations - 11925
Toshiaki Ohteki is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 44, co-authored 99 publications receiving 11150 citations. Previous affiliations of Toshiaki Ohteki include Keio University & Ontario Institute for Cancer Research.
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Critical role for IL-15 in innate immunity.
TL;DR: This review summarizes recent progress of studies in the IL-15/IL-15R system, a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRydelta+ intestinal intraepithelial lymphocytes (ilEL), and for the functional maturation of dendritic cells and macrophages.
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Monocyte-Derived Dendritic Cells Perform Hemophagocytosis to Fine-Tune Excessive Immune Responses
Hideaki Ohyagi,Nobuyuki Onai,Taku Sato,Satoshi Yotsumoto,Jiajia Liu,Hisaya Akiba,Hideo Yagita,Koji Atarashi,Kenya Honda,Axel Roers,Werner Müller,Kazutaka Kurabayashi,Mayuka Hosoi-Amaike,Naoto Takahashi,Makoto Hirokawa,Kouji Matsushima,Kenichi Sawada,Toshiaki Ohteki +17 more
TL;DR: It is shown that when injected with high Toll-like receptor ligand doses or infected with lymphocytic choriomeningitis virus (LCMV) clone 13, inflammatory monocyte-derived dendritic cells (Mo-DCs) engulfed apoptotic erythroid cells, suggesting that hemophagocytosis moderates immune responses to ensure the host's survival in vivo.
Journal Article
Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response.
TL;DR: The findings suggest that the function of Ag-selected CD8 cells may be regulated over time and according to location by subtle changes in cell-surface phenotype.
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Lack of directed V alpha 14-J alpha 281 rearrangements in NK1+ T cells.
TL;DR: It is argued that rigorous ligand selection rather than directed rearrangement is responsible for the high frequency of Vα14‐Jα281 rearrangements in NK1.1+ T cells.
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Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules.
TL;DR: Analysis of anti‐DNA antibodies and rheumatoid factor in serum demonstrates that lprβ2m–/– mice produce comparable levels of autoantibodies to lprWT mice and support the hypothesis that the majority of DN T cells may be derived from cells of the CD8 lineage.