T
Toshiaki Ohteki
Researcher at Tokyo Medical and Dental University
Publications - 101
Citations - 11925
Toshiaki Ohteki is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 44, co-authored 99 publications receiving 11150 citations. Previous affiliations of Toshiaki Ohteki include Keio University & Ontario Institute for Cancer Research.
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Journal ArticleDOI
Role of eosinophils in a murine model of inflammatory bowel disease
Zi Wang,Soichiro Adachi,Lingling Kong,Daisuke Watanabe,Yusuke Nakanishi,Toshiaki Ohteki,Namiko Hoshi,Yuzo Kodama +7 more
TL;DR: The data indicate that eosinophils do not play a significant role in the immunopathology of colitis in IL-10-/- mice.
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IL‐7 is essential for lymphopenia‐driven turnover of colitogenic CD4+ memory T cells in chronic colitis
Takayuki Tomita,Takanori Kanai,Teruji Totsuka,Yasuhiro Nemoto,Ryuichi Okamoto,Kiichiro Tsuchiya,Naoya Sakamoto,Toshiaki Ohteki,Toshifumi Hibi,Mamoru Watanabe +9 more
TL;DR: Results demonstrate that IL‐7 is essential for lymphopenia‐driven turnover of colitogenic CD4+ T cells rather than the maintenance of those cells in established colitic mice and provide a basis for the timing of IL‐ 7/IL‐7R blockade for the treatment of inflammatory bowel diseases.
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IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon
Kana Minamide,Taku Sato,Taku Sato,Yusuke Nakanishi,Hiroshi Ohno,Tamotsu Kato,Jumpei Asano,Toshiaki Ohteki +7 more
TL;DR: It is demonstrated that chronic IFN signaling physiologically stresses CoSCs, and the ability of Irf2ΔIEC mice to regenerate colon epithelium after inducing colitis was severely impaired, independently of microbial dysbiosis.
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Role of SIRPα in regulation of mucosal immunity in the intestine.
Yoshitake Kanazawa,Yoshitake Kanazawa,Yasuyuki Saito,Yana Supriatna,Hiroyuki Tezuka,Hiroyuki Tezuka,Takenori Kotani,Yoji Murata,Yoji Murata,Hideki Okazawa,Hiroshi Ohnishi,Yoshitaka Kinouchi,Yoshihisa Nojima,Toshiaki Ohteki,Toshiaki Ohteki,Tooru Shimosegawa,Takashi Matozaki,Takashi Matozaki +17 more
TL;DR: The data suggest that SIRPα expressed on CD11c+ LP cells is important for the production of IL‐17 or IFN‐γ in the LP as well as for the development of colitis induced by IL‐10 deficiency.
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Propolis induces Ca2+ signaling in immune cells.
Takahiro Adachi,Soichiro Yoshikawa,Soichiro Yoshikawa,Hiroyuki Tezuka,Noriko M. Tsuji,Toshiaki Ohteki,Hajime Karasuyama,Kumazawa Toshihiko +7 more
TL;DR: Intravital imaging of PPs showed that an intraperitoneal injection of propolis augmented Ca2+ signaling in CD11c+ cells, suggesting that propolis possesses immune-stimulating activity.