T
Toshiaki Ohteki
Researcher at Tokyo Medical and Dental University
Publications - 101
Citations - 11925
Toshiaki Ohteki is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 44, co-authored 99 publications receiving 11150 citations. Previous affiliations of Toshiaki Ohteki include Keio University & Ontario Institute for Cancer Research.
Papers
More filters
Journal ArticleDOI
Critical role of IL-15–IL-15R for antigen-presenting cell functions in the innate immune response
TL;DR: It is shown that the IL-15–IL-15R interaction is critical in early activation of antigen-presenting cells and plays an important role in the innate immune system.
Journal ArticleDOI
A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential.
Nobuyuki Onai,Kazutaka Kurabayashi,Mayuka Hosoi-Amaike,Noriko Toyama-Sorimachi,Kouji Matsushima,Kayo Inaba,Toshiaki Ohteki +6 more
TL;DR: These findings provide insight into DC differentiation pathways and may lead to progenitor-based therapeutic applications for infection and autoimmune disease.
Journal ArticleDOI
In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-.
TL;DR: Results show that the NK1.1+ CD4+ cells, responsible for the rapid burst of IL‐4 production after i.v. injection of anti‐CD3, do not contribute to the early IL‐ 4 response to L. major.
Journal Article
Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development.
TL;DR: It is shown here that NK1+ T cells express the IL-2R beta/IL-15R beta that is normally present on conventional NK cells, but not T cells, and it is demonstrated that IL-15 plays a crucial role during development.
Journal ArticleDOI
Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3.
Toshiaki Ohteki,Michael Parsons,Arsen Zakarian,Russell G. Jones,Linh T. Nguyen,James R. Woodgett,Pamela S. Ohashi +6 more
TL;DR: It is demonstrated that GSK-3 negatively regulates the duration of T cell responses, and it is shown that nuclear factor of activated T cells (NF-AT)c remains in the nucleus after antigen-specific stimulation of T cells.