T
Toshihide Iwashita
Researcher at Hamamatsu University School of Medicine
Publications - 86
Citations - 8174
Toshihide Iwashita is an academic researcher from Hamamatsu University School of Medicine. The author has contributed to research in topics: Proto-Oncogene Proteins c-ret & Mutation. The author has an hindex of 29, co-authored 78 publications receiving 7687 citations. Previous affiliations of Toshihide Iwashita include Nagoya University & Aichi Medical University.
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Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
Anna V. Molofsky,Ricardo Pardal,Toshihide Iwashita,In-Kyung Park,Michael F. Clarke,Sean J. Morrison,Sean J. Morrison +6 more
TL;DR: It is shown that Bmi-1 is required for the self-renewal of stem cells in the peripheral and central nervous systems but not for their survival or differentiation but restricted neural progenitors from the gut and forebrain proliferate normally in the absence of B mi-1.
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Neural Crest Stem Cells Persist in the Adult Gut but Undergo Changes in Self-Renewal, Neuronal Subtype Potential, and Factor Responsiveness
Genevieve M. Kruger,Jack T. Mosher,Suzanne Bixby,Nancy M. Joseph,Toshihide Iwashita,Sean J. Morrison +5 more
TL;DR: The persistence of NCSCs in the adult PNS opens up new possibilities for regeneration after injury or disease, and parallel perinatal changes in hematopoietic stem cells suggest that stem cells in different tissues undergo similar developmental transitions.
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Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2a mutations
TL;DR: This result demonstrated that transport of the Ret protein to the plasma membrane is required for its transforming activity, and indicated that MEN 2A mutations induced ligand-independent dimerization of the c-Ret protein on the cell surface, leading to activation of its intrinsic tyrosine kinase.
Journal Article
Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues
Toyonori Tsuzuki,Masahide Takahashi,Nobuyuki Asai,Toshihide Iwashita,Mutsushi Matsuyama,Asai J +5 more
TL;DR: The c-Ret protein was expressed in neural crest cells migrating from rhombomere 4 at day 11.5 and then became positive in the facial, glossopharyngeal and vagus cranial ganglia at day 12.5 which formed the myenteric plexus of the whole embryonic gut and the sympathetic trunk at later stages.