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Ömer H. Yilmaz
Researcher at Massachusetts Institute of Technology
Publications - 177
Citations - 14893
Ömer H. Yilmaz is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Stem cell & Cancer. The author has an hindex of 41, co-authored 158 publications receiving 11712 citations. Previous affiliations of Ömer H. Yilmaz include University of Michigan & Broad Institute.
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Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
Journal ArticleDOI
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Ömer H. Yilmaz,Riccardo Valdez,Brian K. Theisen,Wei Guo,David O. Ferguson,Hong Wu,Sean J. Morrison +6 more
TL;DR: Mechanistic differences between normal stem cells and cancer stem cells can thus be targeted to depletecancer stem cells without damaging normalstem cells.
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A single-cell survey of the small intestinal epithelium
Adam L. Haber,Moshe Biton,Moshe Biton,Noga Rogel,Rebecca H. Herbst,Rebecca H. Herbst,Karthik Shekhar,Christopher Smillie,Grace Burgin,Toni Delorey,Toni Delorey,Michael R. Howitt,Yarden Katz,Itay Tirosh,Semir Beyaz,Danielle Dionne,Mei Zhang,Raktima Raychowdhury,Wendy S. Garrett,Wendy S. Garrett,Orit Rozenblatt-Rosen,Hai Ning Shi,Ömer H. Yilmaz,Ömer H. Yilmaz,Ramnik J. Xavier,Ramnik J. Xavier,Aviv Regev +26 more
TL;DR: This paper reported profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal epithelial cell and their gene signatures.
Journal ArticleDOI
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
Ömer H. Yilmaz,Pekka Katajisto,Dudley W. Lamming,Yetis Gultekin,Yetis Gultekin,Khristian E. Bauer-Rowe,Shomit Sengupta,Kıvanç Birsoy,Abdulmetin Dursun,V. Onur Yilmaz,Martin K. Selig,G. Petur Nielsen,Mari Mino-Kenudson,Lawrence R. Zukerberg,Atul K. Bhan,Vikram Deshpande,David M. Sabatini +16 more
TL;DR: It is found that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem- cell function in response to calorie restriction and mTORC1 non-cell-autonomously regulates stem- Cell self-renewal.
Journal ArticleDOI
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Semir Beyaz,Semir Beyaz,Miyeko D. Mana,Jatin Roper,Jatin Roper,Dmitriy Kedrin,Dmitriy Kedrin,Assieh Saadatpour,Sue Jean Hong,Khristian E. Bauer-Rowe,Michael E. Xifaras,Adam Akkad,Erika Arias,Luca Pinello,Yarden Katz,Shweta Shinagare,Monther Abu-Remaileh,Maria M. Mihaylova,Dudley W. Lamming,Rizkullah Dogum,Guoji Guo,George W. Bell,Martin K. Selig,G. Petur Nielsen,Nitin K. Gupta,Cristina R. Ferrone,Vikram Deshpande,Guo-Cheng Yuan,Stuart H. Orkin,David M. Sabatini,David M. Sabatini,Ömer H. Yilmaz,Ömer H. Yilmaz,Ömer H. Yilmaz +33 more
TL;DR: It is shown that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem cells of the mammalian intestine and highlights how diet-modulated PPAR-δ activation alters not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumours.