T
Toshihiro Tsuruda
Researcher at University of Miyazaki
Publications - 64
Citations - 1488
Toshihiro Tsuruda is an academic researcher from University of Miyazaki. The author has contributed to research in topics: Adrenomedullin & Angiotensin II. The author has an hindex of 18, co-authored 57 publications receiving 1373 citations. Previous affiliations of Toshihiro Tsuruda include Matsumoto Dental University & Minami Kyushu University.
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Journal ArticleDOI
Adrenomedullin: A Possible Autocrine or Paracrine Inhibitor of Hypertrophy of Cardiomyocytes
Toshihiro Tsuruda,Johji Kato,Kazuo Kitamura,Kenji Kuwasako,Takuroh Imamura,Yasushi Koiwaya,Tetsuo Tsuji,Kenji Kangawa,Tanenao Eto +8 more
TL;DR: C cultured neonatal rat cardiomyocytes produce and secrete AM, and the secreted AM inhibits the protein synthesis of these cells, suggesting that AM may act on carduomyocytes as an autocrine or a paracrine factor modulating the cardiac growth.
Journal ArticleDOI
Adrenomedullin: a protective factor for blood vessels.
TL;DR: A body of evidence suggests that AM participates in the mechanism against progression of vascular damage and remodeling, thereby alleviating the ischemia of tissues and organs.
Journal ArticleDOI
Adventitial Mast Cells Contribute to Pathogenesis in the Progression of Abdominal Aortic Aneurysm
Toshihiro Tsuruda,Johji Kato,Kinta Hatakeyama,Kazushi Kojima,Mitsuhiro Yano,Yoshikazu Yano,Kunihide Nakamura,Fukumi Nakamura-Uchiyama,Yoshibumi Matsushima,Takuroh Imamura,Toshio Onitsuka,Yujiro Asada,Yukifumi Nawa,Tanenao Eto,Kazuo Kitamura +14 more
TL;DR: In this article, the authors carried out histological study of abdominal aortic aneurysm (AAA) tissues of patients, and interventional animal and cell culture experiments to investigate a role of mast cells in the pathogenesis of AAA.
Journal ArticleDOI
An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth.
Toshihiro Tsuruda,Johji Kato,Kazuo Kitamura,Mari Kawamoto,Kenji Kuwasako,Takuroh Imamura,Yasushi Koiwaya,Tetsuo Tsuji,Kenji Kangawa,Tanenao Eto +9 more
TL;DR: It is suggested that AM has an important role in modulating the growth of cardiac fibroblasts in an autocrine or a paracrine manner and the secreted AM may inhibit proliferation and protein synthesis of these cells.
Journal ArticleDOI
Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart.
Hiroyuki Masuyama,Toshihiro Tsuruda,Yoko Sekita,Kinta Hatakeyama,Takuroh Imamura,Johji Kato,Yujiro Asada,Johannes-Peter Stasch,Kazuo Kitamura +8 more
TL;DR: It is suggested that sGC stimulator BAY 41–2272 might be effective to reduce fibrosis in hypertensive heart disease by attenuating angiotensin II generation through myofibroblast transformation.