T
Toshimasa Ishizaki
Researcher at Oita University
Publications - 74
Citations - 15854
Toshimasa Ishizaki is an academic researcher from Oita University. The author has contributed to research in topics: MDia1 & Actin cytoskeleton. The author has an hindex of 42, co-authored 68 publications receiving 15248 citations. Previous affiliations of Toshimasa Ishizaki include Max Planck Society & Kyoto University.
Papers
More filters
Journal ArticleDOI
Integrin-dependent translocation of p160ROCK to cytoskeletal complex in thrombin-stimulated human platelets.
Akiko Fujita,Y. Saito,Toshimasa Ishizaki,Midori Maekawa,Kazuko Fujisawa,Fumitaka Ushikubi,Shuh Narumiya +6 more
TL;DR: The results suggest that p160(ROCK) translocates to cytoskeleton in a manner dependent on integrin ligation and works in an early stage of cytoskeletal reorganization in thrombin-stimulated platelets.
Journal ArticleDOI
Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II
Hiroshi Kamijo,Yutaka Matsumura,Dean Thumkeo,Seiichi Koike,Masayuki Masu,Yoshihiko Shimizu,Toshimasa Ishizaki,Shuh Narumiya +7 more
TL;DR: The results suggest that ROCK isoforms function redundantly during embryogenesis and play a critical role in vascular development.
Journal ArticleDOI
Activated Cdc42-Bound IQGAP1 Determines the Cellular Endocytic Site
Toshihide Kimura,Mami Yamaoka,Shigeki Taniguchi,Mitsuhiro Okamoto,Masahiro Takei,Tomomi Ando,Akihiro Iwamatsu,Takashi Watanabe,Kozo Kaibuchi,Toshimasa Ishizaki,Ichiro Niki +10 more
TL;DR: Results indicate that activation of Cdc42 in response to the insulin secretagogue glucose recruits endocytic machinery to IQGAP1 at the cell periphery and regulates endocytosis at this membrane site.
Journal ArticleDOI
Protective effect of hydrogen sulfide on pancreatic beta-cells
TL;DR: Hydrogen sulfide produced by CSE is suggested to be part of a homeostatic mechanism used by pancreatic beta-cells to inhibit insulin release and reduce cellular stress evoked by glucose, possibly via the anti-oxidant properties of H2S.
Journal ArticleDOI
mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion
Masahiro Tanji,Toshimasa Ishizaki,Saman Ebrahimi,Yuko Tsuboguchi,Taiko Sukezane,Tsuyoshi Akagi,Margaret C. Frame,Nobuo Hashimoto,Susumu Miyamoto,Shuh Narumiya +9 more
TL;DR: Transduced mouse embryonic fibroblasts from mDia1-deficient mice with temperature-sensitive v-Src and Rho-mDia 1 signaling facilitates malignant transformation and invasion by manipulating the actin cytoskeleton and targeting Src to the cell periphery are suggested.