Toshio Imai

TL;DR: It is shown that tumor development could be simply induced independently of intestinal microenvironment, even with WT murine primary intestinal cells alone, and indicated that genetic cooperation for intestinal tumorigenesis could be essentially recapitulated in intestinal organoids without generating gene-modified mice.

TL;DR: Manufactured nano/microparticles, CB, C60 and kaolin, were shown to be genotoxic in in vitro and in vivo assay systems.

TL;DR: Green tea catechins, polyphenols extracted from the stalks and leaves of Camellia sinensis, are found in the different types of tea beverages and as antioxidant additives to many foods, snacks, fats and fatty oils and the no observed adverse effect level (NOAEL) of GTC was estimated to be 1.25%.

TL;DR: The results demonstrate tumor-promoting and possible hepatocarcinogenic activity of KA at 2%, but the carcinogenic potential is likely to be weak.

TL;DR: Accumulating evidence suggests that pancreatic FI is involved in PDAC development in animals and humans, and further investigations to clarify the genetic and environmental factors that cause pancreaticFI are warranted.