Toshiya Hirayama

TL;DR: The aim of these studies was to understand the role of TLR signaling in regulation of β-defensin expression by IEC, and to protect the intestinal epithelium from pathogen invasion and from potential invaders among the commensal flora.

TL;DR: The DPKs of the fifth and sixth generation, which have 64 and 128 amine groups on the surface of the molecule, respectively, showed efficient gene transfection ability into several cultivated cell lines without significant cytotoxity.

TL;DR: It is reported that mice deficient in protein tyrosine phosphatase receptor type Z (Ptprz) do not show mucosal damage by VacA, although VacA is incorporated into the gastric epithelial cells to the same extent as in wild-type mice, and pleiotrophin (PTN), an endogenous ligand of Ptprz, induced gastritis specifically in PtprZ+/+ mice when administered orally.

TL;DR: Findings provide a molecular link between H. pylori and gastric carcinogenesis through the specific accumulation of CagA in gastric cancer stem-like cells through thespecific accumulation in gastric cells expressing CD44, a cell-surface marker associated with cancer stem cells.

TL;DR: expression levels of some miRNAs, including let‐7 family members, were significantly altered following infection with a virulent H. pylori strain carrying intact cag pathogenicity island including cagA but not isogenic mutants, providing insights into miRNA involvement in the pathogenesis of H.pylori‐associated gastritis.