K
Kathrin S. Michelsen
Researcher at Cedars-Sinai Medical Center
Publications - 64
Citations - 7302
Kathrin S. Michelsen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: TLR4 & Inflammation. The author has an hindex of 35, co-authored 59 publications receiving 6837 citations. Previous affiliations of Kathrin S. Michelsen include Humboldt University of Berlin & University of California, Los Angeles.
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Journal ArticleDOI
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
Kathrin S. Michelsen,Michelle H. Wong,Prediman K. Shah,Wenxuan Zhang,Juliana Yano,Terence M. Doherty,Shizuo Akira,Tripathi B. Rajavashisth,Moshe Arditi +8 more
TL;DR: An important role for TLR4 and MyD88 signaling in atherosclerosis in a hypercholesterolemic mouse model is suggested, providing a pathophysiologic link between innate immunity, inflammation, and atherogenesis.
Journal ArticleDOI
Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis
Masayuki Fukata,Kathrin S. Michelsen,Rajaraman Eri,Lisa S. Thomas,Bing Hu,Katie Lukasek,Cynthia C. Nast,Juan Lechago,Ruliang Xu,Yoshikazu Naiki,Antoine Soliman,Moshe Arditi,Maria T. Abreu +12 more
TL;DR: DSS treatment of TLR4-/- mice was associated with striking reduction in acute inflammatory cells compared with wild-type mice despite similar degrees of epithelial injury, suggesting that this is the dominant downstream pathway.
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Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut
Gil Y. Melmed,Lisa S. Thomas,Nahee Lee,Samuel Y. Tesfay,Katie Lukasek,Kathrin S. Michelsen,Yuehua Zhou,Bing Hu,Moshe Arditi,Maria T. Abreu +9 more
TL;DR: The relative absence of TLR2 protein expression by IEC and high level of Tollip expression may be important in preventing chronic proinflammatory cytokine secretion in response to commensal Gram-positive bacteria in the gut.
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Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway.
Yonca Bulut,Emmanuelle Faure,Lisa S. Thomas,Hisae Karahashi,Kathrin S. Michelsen,Ozlem Equils,Sandra G. Morrison,Richard P. Morrison,Moshe Arditi +8 more
TL;DR: Results indicate that cHSP60 is a potent inducer of vascular EC and macrophage inflammatory responses, which are very relevant to atherogenesis.
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HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
James F. Curtin,James F. Curtin,Naiyou Liu,Naiyou Liu,Marianela Candolfi,Marianela Candolfi,Weidong Xiong,Weidong Xiong,Hikmat Assi,Hikmat Assi,Kader Yagiz,Kader Yagiz,Matthew R. Edwards,Kathrin S. Michelsen,Kurt M. Kroeger,Kurt M. Kroeger,Chunyan Liu,Chunyan Liu,A.K.M. Ghulam Muhammad,A.K.M. Ghulam Muhammad,Mary C. Clark,Mary C. Clark,Moshe Arditi,Begonya Comin-Anduix,Antoni Ribas,Pedro R. Lowenstein,Maria G. Castro +26 more
TL;DR: Evidence is provided for the molecular and cellular mechanisms that support the rationale for the clinical implementation of antibrain cancer immunotherapies in combination with tumor killing approaches in order to elicit effective antitumor immune responses, and thus, will impact clinical neuro-oncology practice.