Toshiyuki Ogata

TL;DR: It is suggested that particle irradiation suppresses metastatic potential even at lower doses, whereas photon irradiation promotes cell migration and invasive capabilities at lower dose level, and preclinical evidence that ion beam radiotherapy may be superior to conventional photon beam therapy in possible preventive effects on metastases of irradiated malignant tumor cells is provided.

TL;DR: This paper briefly reviews the current knowledge of the biological aspects of heavy-ion therapy, and focuses on the authors' recent findings on repair mechanisms of heavy ion-induced DNA damage.

TL;DR: Monotherapeutic HDR brachytherapy with an extreme hypofractionation regimen of 54 Gy in nine fractions associated with hormonal therapy was feasible, and its toxicity was acceptable, even for patients with locally advanced disease.

TL;DR: It is found that in vitro angiogenesis was inhibited by high linear energy transfer carbon ion irradiation even at sublethal dose (0.1 Gy), providing an implication that heavy ion beam therapy could be superior to conventional photon beam therapy in preventive effects on in vitroAngiogenesis even atSublethal dose, and might inhibit angiogenic in vivo.

TL;DR: The results suggest that carbon ion irradiation effectively suppresses the metastatic potential of A549 cells by suppressing the PI3K/Akt signaling pathway.