T
Toshiyuki Ohtsuka
Researcher at Kyoto University
Publications - 91
Citations - 10729
Toshiyuki Ohtsuka is an academic researcher from Kyoto University. The author has contributed to research in topics: HES1 & Notch signaling pathway. The author has an hindex of 45, co-authored 78 publications receiving 10003 citations. Previous affiliations of Toshiyuki Ohtsuka include Stanford University.
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Journal ArticleDOI
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Itaru Imayoshi,Masayuki Sakamoto,Toshiyuki Ohtsuka,Keizo Takao,Keizo Takao,Tsuyoshi Miyakawa,Tsuyoshi Miyakawa,Masahiro Yamaguchi,Kensaku Mori,Toshio Ikeda,Shigeyoshi Itohara,Ryoichiro Kageyama +11 more
TL;DR: It is suggested that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory.
Journal ArticleDOI
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.
Toshiyuki Ohtsuka,Makoto Ishibashi,Makoto Ishibashi,Gerald Gradwohl,Shigetada Nakanishi,François Guillemot,Ryoichiro Kageyama +6 more
TL;DR: It is demonstrated that Hes1 and Hes5 are essential Notch effectors in regulation of mammalian neuronal differentiation in neural precursor cells prepared from wild‐type, Hes1‐null, Hes5‐null and Hes1-Hes5 double‐null mouse embryos.
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Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.
Hiromi Hirata,Shigeki Yoshiura,Toshiyuki Ohtsuka,Yasumasa Bessho,Takahiro Harada,Kenichi Yoshikawa,Ryoichiro Kageyama +6 more
TL;DR: It is shown that serum treatment of cultured cells induces cyclic expression of both mRNA and protein of the Notch effector Hes1, a basic helix-loop-helix (bHLH) factor, with 2-hour periodicity, which may regulate timing in many biological systems.
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Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors
TL;DR: It is found that Hes1 expression dynamically oscillates in neural progenitors, and sustained overexpression of Hes1 downregulates expression of proneural genes, Notch ligands, and cell cycle regulators, suggesting that their proper expression depends on Hes1 oscillation.
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The Hes gene family: repressors and oscillators that orchestrate embryogenesis
TL;DR: This primer describes the pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis.