Showing papers by "Toshiyuki Yamamoto published in 2001"

High expression and autoinduction of monocyte chemoattractant protein‐1 in scleroderma fibroblasts

Abstract: Systemic sclerosis (SSc) is a connective tissue disease with unknown etiology characterized by excessive deposition of extracellular matrix in the skin as well as various internal organs. In the early stages of SSc, inflammatory infiltrates of mononuclear cells are found in the dermis, which is associated with increased collagen synthesis produced by activated fibroblasts. Monocyte chemoattractant protein-1 (MCP-1) is a predominant monocyte chemoattractant secreted by a variety of cell types, and recent in vivo and in vitro studies suggest the involvement of MCP-1 in tissue fibrosis. Here we demonstrate that cultured scleroderma fibroblasts, compared to fibroblasts from control skin, spontaneously express significantly elevated MCP-1 levels. Interestingly, exogenously administered MCP-1 stimulated autoinduction of MCP-1 mRNA. This effect was specific to scleroderma fibroblasts and abrogated by actinomycin D. These findings suggest that MCP-1 plays an important role in the induction of scleroderma by MCP-1 release from fibroblasts, which results in recruitment of monocytes to the skin. Moreover, increased responsiveness of scleroderma fibroblasts to MCP-1 could result in a continuation of the fibrotic response.

Acute exanthematous pustular drug eruption induced by mexiletine.

Abstract: A 56-year-old man developed infiltrated erythemas on the trunk, extremities, and face with marked facial edema, one month after taking mexiletine hydrochloride for his arrhythmia. A number of pustules were also noted on the surface of erythemas on his chest and face. Laboratory examination showed liver dysfunction and hypereosinophilia. The culture from pustules was sterile. Histological examination of the biopsied skin from a pustular lesion revealed a subcorneal abscess, and perivascular infiltration of lymphocytes, mononuclear cells and eosinophils in the upper dermis. The skin lesions and facial edema as well were improved within three weeks by withdrawal of mexiletine hydrochloride. Patch tests with 10% and 20% mexiletine hydrochloride in petrolatum showed positive reaction, however, pustules were not provoked on the tested site. We conclude that pustules, infiltrated erythema and facial edema were the signs of acute exanthematous pustular drug eruption induced by mexiletine hydrochloride.

Increased serum level of vascular endothelial growth factor in Crow-Fukase syndrome.

Abstract: reactions to chemotherapy. J Am Acad Dermatol 1999; 40: is not indicated by the dermatological Ž ndings alone, because 367–398. the reaction is self-limited (2). 3. Chu CY, Yang CH, Yang CY, Hsiao GH, Chiu HC. Fixed erythrodysaesthesia plaque due to intravenous injection of docetREFERENCES axel. Br J Dermatol 2000; 142: 808–811. 4. Greer KE, Hawkins H, Hess C. Leser-Trelat associated with acute 1. Vanhooteghem O, Richert B, Vindevoghel A, Vandenbossche L, leukemia. Arch Dermatol 1978; 114: 1552. Vandeveire A, de la Brassinne M. Subungual abscess: a new ungual 5. Kechijian P, Sadick NS, Mariglio J, Schulman P. Cytarabineside-eVect related to docetaxel therapy. Br J Dermatol 2000; induced in ammation in the seborrheic keratoses of Leser-Trelat. 143: 462–464. 2. Susser WS, Whitaker-Worth DL, Grant-Kels JM. Mucocutaneous Ann Intern Med 1979; 91: 868–869.

Unusual annular erythema associated with myelodysplastic syndrome.

Abstract: We report a case of unusual annular erythema associated with myelodysplastic syndrome (MDS). A 58-year-old male with MDS developed annular erythema on his back, scaly erythema on the dorsa of hands, and exsudative erythema on his eyelids. Histological examination revealed a mononuclear cell infiltrate around vessels and follicles in the mid- to lower dermis. He had no history of treatment with granulocyte-colony-stimulating factor (G-CSF). Serum granulocyte-macrophage-colony-stimulating factor (GM-CSF) level was slightly elevated (5.84 pg/ml, normal <2.0 pg/ml), whereas other cytokines including G-CSF, IL-6, and IL-8 were within normal limits. Skin manifestations were much improved by systemic mepitiostane, and serum GM-CSF level returned to normal levels.