T
Travis J. Cook
Researcher at University of Washington
Publications - 9
Citations - 787
Travis J. Cook is an academic researcher from University of Washington. The author has contributed to research in topics: Parkinson's disease & Alzheimer's disease. The author has an hindex of 7, co-authored 9 publications receiving 595 citations.
Papers
More filters
Journal ArticleDOI
Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease
Min Shi,Changqin Liu,Travis J. Cook,Kristin M. Bullock,Kristin M. Bullock,Yanchun Zhao,Carmen Ginghina,Yanfei Li,Patrick Aro,Romel P Dator,Chunmei He,Michael J. Hipp,Cyrus P. Zabetian,Cyrus P. Zabetian,Elaine R. Peskind,Elaine R. Peskind,Shu Ching Hu,Shu Ching Hu,Joseph F. Quinn,Douglas Galasko,William A. Banks,William A. Banks,Jing Zhang +22 more
TL;DR: It is discovered that CSF α-synuclein was readily transported to blood, with a small portion being contained in exosomes that are relatively specific to the central nervous system (CNS), which may lead to a more convenient and robust assessment of Parkinson’s disease clinically.
Journal ArticleDOI
CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease
Min Shi,Andrej Kovac,Andrej Kovac,Andrej Kovac,Ane Korff,Travis J. Cook,Carmen Ginghina,Kristin M. Bullock,Kristin M. Bullock,Li Yang,Tessandra Stewart,Danfeng Zheng,Danfeng Zheng,Patrick Aro,Anzari Atik,Kathleen F. Kerr,Cyrus P. Zabetian,Cyrus P. Zabetian,Elaine R. Peskind,Elaine R. Peskind,Shu Ching Hu,Shu Ching Hu,Joseph F. Quinn,Douglas Galasko,Thomas J. Montine,William A. Banks,William A. Banks,Jing Zhang,Jing Zhang +28 more
TL;DR: Alzheimer's disease and Parkinson's disease involve tau pathology, where Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.
Journal ArticleDOI
DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease
Xiangmin Lin,Travis J. Cook,Cyrus P. Zabetian,Cyrus P. Zabetian,James B. Leverenz,Elaine R. Peskind,Elaine R. Peskind,Shu-Ching Hu,Kevin C. Cain,Catherine Pan,John Scott Edgar,David R. Goodlett,Brad A. Racette,Harvey Checkoway,Thomas J. Montine,Min Shi,Jing Zhang +16 more
TL;DR: Blood levels of patients with Parkinson disease at various stages, Alzheimer disease, and healthy controls are measured to identify potential peripheral biomarkers of PD, suggesting that post-translationally modified isoforms of DJ-1 from whole blood are candidate biomarker of late-stage Parkinson disease.
Journal ArticleDOI
Biomarkers of Parkinson's disease: current status and future perspectives.
TL;DR: This review summarizes major advances in biomarker discovery for diagnosis, differential diagnosis and progression of Parkinson's disease, with emphasis on neuroimaging and biochemical markers.
Journal ArticleDOI
Astrocytic Dynamin-Like Protein 1 Regulates Neuronal Protection against Excitotoxicity in Parkinson Disease
Jake G. Hoekstra,Travis J. Cook,Tessandra Stewart,Hayley A. Mattison,Max T. Dreisbach,Zachary S. Hoffer,Jing Zhang +6 more
TL;DR: It is suggested that astrocytic mitochondrial Dlp1 is a key protein in mitochondrial dynamics and decreased DLP1 may interfere with neuron survival in PD by disrupting Ca(2+)-coupled glutamate uptake.