R
Romel P Dator
Researcher at University of Minnesota
Publications - 18
Citations - 847
Romel P Dator is an academic researcher from University of Minnesota. The author has contributed to research in topics: Carcinogen & DNA damage. The author has an hindex of 9, co-authored 16 publications receiving 634 citations. Previous affiliations of Romel P Dator include University of Cincinnati & University of Washington.
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Journal ArticleDOI
Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease
Min Shi,Changqin Liu,Travis J. Cook,Kristin M. Bullock,Kristin M. Bullock,Yanchun Zhao,Carmen Ginghina,Yanfei Li,Patrick Aro,Romel P Dator,Chunmei He,Michael J. Hipp,Cyrus P. Zabetian,Cyrus P. Zabetian,Elaine R. Peskind,Elaine R. Peskind,Shu Ching Hu,Shu Ching Hu,Joseph F. Quinn,Douglas Galasko,William A. Banks,William A. Banks,Jing Zhang +22 more
TL;DR: It is discovered that CSF α-synuclein was readily transported to blood, with a small portion being contained in exosomes that are relatively specific to the central nervous system (CNS), which may lead to a more convenient and robust assessment of Parkinson’s disease clinically.
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In Vivo X-Ray Footprinting of Pre-30S Ribosomes Reveals Chaperone-Dependent Remodeling of Late Assembly Intermediates
TL;DR: The results indicate that cellular factors delay specific RNA folding steps to ensure the quality of assembly, and widespread differences between mature and pre-30S complexes in the absence of assembly factors RbfA and RimM revealed global reorganization of RNA-protein interactions prior to maturation of the 16S rRNA.
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The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse.
Carol J. Díaz-Díaz,Sean Ronnekleiv-Kelly,Manabu Nukaya,Peter G. Geiger,Silvia Balbo,Romel P Dator,Bryant Megna,Patrick R. Carney,Christopher A. Bradfield,Gregory D. Kennedy,Gregory D. Kennedy +10 more
TL;DR: This study finds that AHR plays a protective role in colitis-associated colorectal tumorigenesis and supports the use of AHR agonists such as I3C as a chemopreventive therapy for IBD-associated CRC in human patients.
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Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation
Min Shi,James Movius,Romel P Dator,Patrick Aro,Yanchun Zhao,Catherine Pan,Xiangmin Lin,Theo K. Bammler,Tessandra Stewart,Cyrus P. Zabetian,Elaine R. Peskind,Shu Ching Hu,Shu Ching Hu,Joseph F. Quinn,Douglas Galasko,Jing Zhang +15 more
TL;DR: A novel panel of CSF peptides, derived from SPP1, LRP1, CSF1R, EPHA4, and TIMP 1, could be used to assist in clinical diagnosis of PD and has the potential to help monitoring or predicting disease progression.
Journal ArticleDOI
Targeted discovery and validation of plasma biomarkers of Parkinson's disease.
Catherine Pan,Yong Zhou,Romel P Dator,Carmen Ginghina,Yanchun Zhao,James Movius,Elaine R. Peskind,Cyrus P. Zabetian,Joseph F. Quinn,Douglas Galasko,Tessandra Stewart,Min Shi,Jing Zhang +12 more
TL;DR: It is possible to use a targeted approach to identify otherwise very difficult to detect CNS related biomarkers in peripheral blood and the novel biomarkers, if validated in independent cohorts, can be employed to assist with clinical diagnosis of PD as well as monitoring disease progression.