Min Shi

TL;DR: It is demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration.

TL;DR: It is discovered that CSF α-synuclein was readily transported to blood, with a small portion being contained in exosomes that are relatively specific to the central nervous system (CNS), which may lead to a more convenient and robust assessment of Parkinson’s disease clinically.

TL;DR: It is demonstrated that a decrease in DJ‐1 and/or α‐synuclein in the cerebrospinal fluid is a potential index for Parkinson disease diagnosis, but not for PD severity.

TL;DR: In this paper, a highly sensitive and specific assay was established and used to measure PS-129 together with total α-synuclein in the CSF of patients with Parkinson's disease, other parkinsonian disorders such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and healthy individuals (a total of ~600 samples).

TL;DR: It is concluded in a recent investigation that, unlike CSF, these two markers in plasma are unable to differentiate patients with Parkinson's disease from controls, and an effort to look for other potential sources of clinically accessible samples for Parkinson's Disease diagnosis is looked for.