T
Tsui Ting Ching
Researcher at National Yang-Ming University
Publications - 24
Citations - 1890
Tsui Ting Ching is an academic researcher from National Yang-Ming University. The author has contributed to research in topics: Phosphatidylinositol (3,4,5)-trisphosphate & Caenorhabditis elegans. The author has an hindex of 15, co-authored 21 publications receiving 1768 citations. Previous affiliations of Tsui Ting Ching include University of Kentucky & University of Michigan.
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The Cyclooxygenase-2 Inhibitor Celecoxib Induces Apoptosis by Blocking Akt Activation in Human Prostate Cancer Cells Independently of Bcl-2
TL;DR: The data demonstrate that inhibition of Akt activation may play a crucial role in the induction of apoptosis by celecoxib, supported by studies showing that overexpression of constitutively active Akt protects PC-3 cells from Celecoxib-induced apoptosis.
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Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation.
TL;DR: It is reported that global hypomethylation is common in primary human glioblastomas [glioblastoma multiforme (GBM] and can affect up to an estimated 10 million CpG dinucleotides per haploid tumor genome, and that MTHFR deficiency-associated demethylation leads to increased proliferative activity in GBM.
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HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity
TL;DR: Findings point to DDL-1/2 as a link between IIS and the HSF-1 pathway, which increases longevity and thermotolerance in an hsf-1-dependent manner.
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Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3
Tsui Ting Ching,Alika K. Maunakea,Peter Jun,Chibo Hong,Giuseppe Zardo,Daniel Pinkel,Donna G. Albertson,Jane Fridlyand,Jian-Hua Mao,Ksenya Shchors,William A. Weiss,Joseph F. Costello +11 more
TL;DR: A method for high-resolution analysis of the methylation status of CpG islands genome-wide, using arrays of BAC clones and themethylation-sensitive restriction enzyme NotI is developed, demonstrating the accuracy and specificity of the method.
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Distinct ligand binding sites in integrin α3β1 regulate matrix adhesion and cell–cell contact
Feng Zhang,Clifford Tom,Matthias C. Kugler,Tsui Ting Ching,Jordan A. Kreidberg,Ying Wei,Harold A. Chapman +6 more
TL;DR: It is concluded that α3β1 regulates both cell–cell contact and matrix adhesion, but through distinct protein interaction sites within its β-propeller, which reveals an integrin- and Src-dependent pathway for SLUG expression and mesenchymal transition.